Copper-Catalyzed Enantioselective Propargylic Amination of Nonaromatic Propargylic Esters with Amines

被引：60

作者：

Yoshida, Akiko ^{[1
]}

Hattori, Gaku ^{[1
]}

Miyake, Yoshihiro ^{[1
]}

Nishibayashi, Yoshiaki ^{[1
]}

机构：

[1] Univ Tokyo, Sch Engn, Inst Engn Innovat, Bunkyo Ku, Tokyo 1138656, Japan

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 09期

关键词：

SUBSTITUTION-REACTIONS; ASYMMETRIC HYDROGENATION; ALLENYLIDENE COMPLEXES; REDUCTIVE CYCLIZATION; ALCOHOLS; ALDEHYDES; ACETATES; INDOLES;

D O I：

10.1021/ol200703g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantioselective propargylic amination of propargylic pentafluorobenzoates bearing an alkyl group at the propargylic position with amines in the presence of catalytic amounts of a copper complex and an optically active diphosphine such as BINAP has been found to give the corresponding propargylic amines in good yields with high enantioselectivity.

引用

页码：2460 / 2463

页数：4

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