Enantioselective Copper-Catalyzed Decarboxylative Propargylic Alkylation of Propargylic Esters with β-Keto Acids

被引：51

作者：

Zhu, Fu-Lin ^{[1
,2
]}

Wang, Ya-Hui ^{[1
]}

Zhang, De-Yang ^{[1
,2
]}

Hu, Xin-Hu ^{[1
]}

Chen, Song ^{[1
]}

Hou, Chuan-Jin ^{[1
,3
]}

Xu, Jie ^{[1
]}

Hu, Xiang-Ping ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Dalian Polytech Univ, Dalian 116034, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2014年 / 356卷 / 14-15期

关键词：

asymmetric catalysis; copper; decarboxylative propargylic alkylation; beta-keto acids; propargylic esters; CONJUGATE ADDITION; SUBSTITUTION-REACTIONS; 3-HYDROXY OXINDOLES; TERMINAL ALKYNES; MANNICH REACTION; KETOACIDS; ACETATES; AMINATION; ALCOHOLS; AMINES;

D O I：

10.1002/adsc.201400218

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The first copper-catalyzed intermolecular enantioselective decarboxylative propargylic alkylation of propargylic esters with beta-keto acids as surrogates of ketones has been successfully developed by using a ketimine P, N, N-ligand. High yields and excellent enantioselectivities (up to 98% ee) have been achieved under the mild reaction conditions.

引用

页码：3231 / 3236

页数：6

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