Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata

被引：114

作者：

Park, Ki Hun

Park, Yong-Dae

Han, Jong-Min

Im, Kyung-Ran

Lee, Byong Won

Jeong, Il Yun

Jeong, Tae-Sook ^{[1
]}

Lee, Woo Song

机构：

[1] Korea Res Inst Biosci & Biotechnol, Natl Res Lab Lipid Metab & Atherosclerosis, Insect Resources Res Ctr, Taejon 3806, South Korea

[2] Univ Sci & Technol, Taejon 305333, South Korea

[3] Gyeongsang Natl Univ, Div Appl Life Sci, Dept Agr Chem, Inst Agr & Life Sci,BK21 Program, Jinju 660701, South Korea

[4] Korea Atom Energy Res Inst, Adv Radiat Technol Inst, Jeongeup 580185, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 21期

关键词：

LDL-antioxidant; ACAT inhibitor; RAW264.7; cells; nitric oxide;

D O I：

10.1016/j.bmcl.2006.08.032

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The catecholic xanthones and flavonoids 1-13 were isolated from the root bark of Cudrania tricuspidata. Compounds I and 3-8 exhibited significant antioxidant activity against low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance (TBARS) assay. Among them, prenylated flavonoids 10-12 showed an inhibitory effect on the NO production and iNOS expression in RAW264.7 cells. Also, compounds 1, 2, 5, 7, 9, and 11 preferentially inhibited hACAT-2 than hACAT-1, whereas compounds 3, 4, 6, and 8 showed a similar specificity against hACAT-1 and -2. However, flavonoids 10, 12, and 13 dominantly inhibited hACAT-2, not hACAT-1. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：5580 / 5583

页数：4

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