Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata

被引：114
|
作者：
Park, Ki Hun
Park, Yong-Dae
Han, Jong-Min
Im, Kyung-Ran
Lee, Byong Won
Jeong, Il Yun
Jeong, Tae-Sook [1 ]
Lee, Woo Song
机构：
[1] Korea Res Inst Biosci & Biotechnol, Natl Res Lab Lipid Metab & Atherosclerosis, Insect Resources Res Ctr, Taejon 3806, South Korea
[2] Univ Sci & Technol, Taejon 305333, South Korea
[3] Gyeongsang Natl Univ, Div Appl Life Sci, Dept Agr Chem, Inst Agr & Life Sci,BK21 Program, Jinju 660701, South Korea
[4] Korea Atom Energy Res Inst, Adv Radiat Technol Inst, Jeongeup 580185, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 21期
关键词：
LDL-antioxidant; ACAT inhibitor; RAW264.7; cells; nitric oxide;
D O I：
10.1016/j.bmcl.2006.08.032
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The catecholic xanthones and flavonoids 1-13 were isolated from the root bark of Cudrania tricuspidata. Compounds I and 3-8 exhibited significant antioxidant activity against low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance (TBARS) assay. Among them, prenylated flavonoids 10-12 showed an inhibitory effect on the NO production and iNOS expression in RAW264.7 cells. Also, compounds 1, 2, 5, 7, 9, and 11 preferentially inhibited hACAT-2 than hACAT-1, whereas compounds 3, 4, 6, and 8 showed a similar specificity against hACAT-1 and -2. However, flavonoids 10, 12, and 13 dominantly inhibited hACAT-2, not hACAT-1. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5580 / 5583
页数：4
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