Synthesis and evaluation of PDE5 inhibitory activity of novel pyrido[2′,1′ : 5,1]pyrazolo[4,3-d]pyrimidin-4-one derivatives

被引：3
|
作者：
Tian Guang-Hui [1 ]
Xia Guang-Xia
Jin Wei-Xi
Chen Xin-Jian
Lai Shun-An
Wei Ya-Bing
Ji Ru-Yun
Shen Jing-Shan
机构：
[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
[2] Nanjing Technol Univ, Nanjing 210009, Jiangsu, Peoples R China
[3] Topharman Shanghai Co Ltd, Shanghai 201209, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2007年 / 25卷 / 02期
关键词：
D O I：
10.1002/cjoc.200790048
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Novel pyridopyrazolopyrimidinone derivatives were designed and synthesized as potential PDE5 inhibitors. The target compounds demonstrated significant inhibitory activity against human platelet PDE5, but less potent than sildenafil.
引用
收藏
页码：241 / 245
页数：5
相关论文
共 50 条
  • [31] A facile synthesis and biological activity of novel tetrahydrobenzo[4′,5′] thieno[3′,2′:5,6]pyrido[4,3-d]pyrimidin-4(3H)-ones
    Ren, Qingyun
    Liang, Yong-Ju
    He, Hongwu
    Fu, Liwu
    Gu, Yucheng
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (23) : 6713 - 6716
  • [32] 1H-pyrazolo[4,3-d]pyrimidine-7(6H)-one and 5H-pyrazolo[4,3-d] 1,2,3-triazin-4(3H)-one derivatives - Synthesis and in vitro biological activity at adenosine A(1) and A(2a) receptors
    Baraldi, PG
    Cacciari, B
    Dalpiaz, A
    Dionisotti, S
    Zocchi, C
    delasInfantas, MJP
    Spalluto, G
    Varani, K
    ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 1996, 46 (04): : 365 - 368
  • [33] New routes to pyridino[2,3-d]pyrimidin-4-one and pyridino-[2,3-d]triazolino[4,5-a]pyrimidin-5-one derivatives
    Hassneen, HM
    Abdallah, TA
    MOLECULES, 2003, 8 (03): : 333 - 341
  • [34] Synthesis and structure of 2-substituted thieno[3′,2′:5,6]pyrido[4,3-d]pyrimidin-4(3H)-one derivatives
    Liu, Jian-Chao
    He, Hong-Wu
    Ding, Ming-Wu
    HELVETICA CHIMICA ACTA, 2007, 90 (05) : 999 - 1005
  • [35] SYNTHESIS OF 2-AMINO-6,7-DIHYDROTHIENO-[3',2'-5,6]PYRIDO[2,3-D]PYRIMIDIN-4-ONE
    TAYLOR, EC
    PONT, JL
    WARNER, JC
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1988, 25 (06) : 1733 - 1735
  • [36] STUDIES ON PYRIDOPYRIMIDINES .1. SYNTHESIS OF PYRAZOLO-[3',4'-4,5]PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES
    NOGUCHI, M
    NAGATA, S
    KAJIGAESHI, S
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1986, 34 (10) : 3994 - 4000
  • [37] 9-HYDROXY-2-METHYL-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 9-HYDROXY-2-PHENYL4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 9-METHYL-2-PHENYL-4H-PYRIDO[1,2-A]-PYRIMIDIN-4-ONE, ETHYL 9-HYDROXY-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE-3-CARBOXYLATE AND THEIR DERIVATIVES
    YALE, HL
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1975, 12 (02) : 427 - 431
  • [38] Synthesis of new pyrazolo[5,1-c][1,2,4] benzotriazines, pyrazolo[5,1-c]pyrido[4,3-e][1,2,4] triazines and their open analogues as cytotoxic agents in normoxic and hypoxic conditions
    Ciciani, Giovanna
    Coronnello, Marcella
    Guerrini, Gabriella
    Selleri, Silvia
    Cantore, Miriam
    Failli, Paola
    Mini, Enrico
    Costanzo, Annarella
    BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (21) : 9409 - 9419
  • [39] Synthesis and antitumor activity of benzo[6",7"] cyclohepta[1",2":4′,5′] pyrido[2′,3′-d] [1,2,4] triazolo[4,3-a]pyrimidin-5-ones
    Edrees, Mastoura M.
    Farghaly, Thoraya A.
    ARABIAN JOURNAL OF CHEMISTRY, 2017, 10 : S1613 - S1618
  • [40] Synthesis of some novel 5-substituted benzamido-6-arylamino-pyrazolo[3,4-D]pyrimidin-4-one derivatives for herbicidal activity
    Luo, Jin
    Li, Shu
    Kang, Qiongwen
    Sun, Yi
    Wang, Tao
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2019, 194 (12) : 1180 - 1186
12345