Synthesis and evaluation of PDE5 inhibitory activity of novel pyrido[2′,1′ : 5,1]pyrazolo[4,3-d]pyrimidin-4-one derivatives

被引：3
|
作者：
Tian Guang-Hui [1 ]
Xia Guang-Xia
Jin Wei-Xi
Chen Xin-Jian
Lai Shun-An
Wei Ya-Bing
Ji Ru-Yun
Shen Jing-Shan
机构：
[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
[2] Nanjing Technol Univ, Nanjing 210009, Jiangsu, Peoples R China
[3] Topharman Shanghai Co Ltd, Shanghai 201209, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2007年 / 25卷 / 02期
关键词：
D O I：
10.1002/cjoc.200790048
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Novel pyridopyrazolopyrimidinone derivatives were designed and synthesized as potential PDE5 inhibitors. The target compounds demonstrated significant inhibitory activity against human platelet PDE5, but less potent than sildenafil.
引用
收藏
页码：241 / 245
页数：5
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