Synthesis and evaluation of PDE5 inhibitory activity of novel pyrido[2′,1′ : 5,1]pyrazolo[4,3-d]pyrimidin-4-one derivatives

被引：3
|
作者：
Tian Guang-Hui [1 ]
Xia Guang-Xia
Jin Wei-Xi
Chen Xin-Jian
Lai Shun-An
Wei Ya-Bing
Ji Ru-Yun
Shen Jing-Shan
机构：
[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
[2] Nanjing Technol Univ, Nanjing 210009, Jiangsu, Peoples R China
[3] Topharman Shanghai Co Ltd, Shanghai 201209, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2007年 / 25卷 / 02期
关键词：
D O I：
10.1002/cjoc.200790048
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Novel pyridopyrazolopyrimidinone derivatives were designed and synthesized as potential PDE5 inhibitors. The target compounds demonstrated significant inhibitory activity against human platelet PDE5, but less potent than sildenafil.
引用
收藏
页码：241 / 245
页数：5
相关论文
共 50 条
  • [21] A new synthesis of pyrido[4,3-d]pyrimidin-2-ones
    A. A. Fesenko
    A. D. Shutalev
    Chemistry of Heterocyclic Compounds, 2013, 49 : 949 - 951
  • [22] A new synthesis of pyrido[4,3-d]pyrimidin-2-ones
    Fesenko, A. A.
    Shutalev, A. D.
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2013, 49 (06) : 949 - 951
  • [23] Synthesis and biological activity of novel Pyrazolo[3,4-d]pyrimidin-4-one derivatives as potent antifungal agent
    Wang, Wei
    Cheng, Xiang
    Cui, Xue
    Xia, Dongguo
    Wang, Ziqing
    Lv, Xianhai
    PEST MANAGEMENT SCIENCE, 2021, 77 (07) : 3529 - 3537
  • [24] Synthesis and herbicidal activity of novel pyrazolo[3,4-d]pyrimidin-4-one derivatives containing aryloxyphenoxypropionate moieties
    Liu, Hui
    Wang, Hong-Qing
    Liu, Zhao-He
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (08) : 2203 - 2209
  • [25] A novel synthesis and herbicidal activity of fluorine-containing pyrazolo[3,4-d]pyrimidin-4-one derivatives
    Liu, Hui
    Wang, Hong-Qing
    Ding, Ming-Wu
    Liu, Zhao-Jie
    Xiao, Wen-Jing
    JOURNAL OF FLUORINE CHEMISTRY, 2006, 127 (12) : 1584 - 1590
  • [26] PYRIDOPYRIMIDINES .4. PREPARATION OF PYRIDO[4,3-D]PYRIMIDINES FROM PRYANO[4,3-D]PYRIMIDIN-5-ONES
    ISMAIL, AG
    WIBBERLE.DG
    JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1968, (22): : 2706 - &
  • [27] Reaction of pyridothiouracil with hydrazonoyl halides and the antimicrobial activity of the products, pyrido[2,3-d][1,2,4]triazolo-[4,3-a]pyrimidin-5(1H)- one derivatives
    Department of Chemistry, Faculty of Science, University of Cairo, Giza, Egypt
    J. Sulfur Chem., 2006, 4 (329-339):
  • [28] Microwave Assisted Synthesis of 2,3-Dihydro-4H- furo[2,3-d]pyrido[1,2-a]pyrimidin-4-ones and furo[2,3-d]pyrido[1,2-a]pyrimidin-4-one
    Yalduz, Sumeyye
    Yilmaz, Mehmet
    CHEMISTRYSELECT, 2023, 8 (10):
  • [29] SYNTHESIS OF PYRAZOLE DERIVATIVES AND PYRAZOLO [4,3-D]PYRIMIDINES .1.
    BARALDI, PG
    VICENTINI, CB
    SIMONI, D
    GUARNERI, M
    FARMACO-EDIZIONE SCIENTIFICA, 1983, 38 (06): : 369 - 375
  • [30] Synthesis and Anticancer Activity of Some New Pyrazolo[3,4-d]pyrimidin-4-one Derivatives
    Abdellatif, Khaled R. A.
    Abdelall, Eman K. A.
    Abdelgawad, Mohamed A.
    Ahmed, Rasha R.
    Bakr, Rania B.
    MOLECULES, 2014, 19 (03) : 3297 - 3309
12345