Synthesis of 1,2,3-triazole glycosides as anticancer agents

被引：0
|
作者：
Srinivas, A. [1 ]
Sunitha, M. [1 ]
机构：
[1] Vaagdevi Degree & PG Coll, Dept Chem, Warangal 506001, Andhra Pradesh, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2016年 / 55卷 / 02期
关键词：
O-Methyl allose; triazole glycosides; click reaction; ZrCl4; anticancer activity; CLICK CHEMISTRY; EXPEDIENT SYNTHESIS; IN-SITU; ACETYLCHOLINESTERASE; INHIBITOR; TRIAZOLE;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of novel 1,2,3-Triazole glycosides have been prepared by the addition reaction of O-methyl allose aldehyde with Grignard reagent. Subsequent treatment with TMSN3 gives the corresponding azide, which on reaction with alkynes gives 1,2,3-triazole glycosides. Characterization of all the compounds has been carried out by IR, H-1 NMR, mass spectroscopy and elemental analysis. Anticancer activity of the compounds has also been evaluated.
引用
收藏
页码：231 / 239
页数：9
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