2-PHENYLPYRROLE: ONE-POT SELECTIVE SYNTHESIS FROM ACETOPHENONE OXIME AND ACETYLENE BY A TROFIMOV REACTION

被引：0

作者：

Mikhaleva, A. I. ^{[1
]}

Petrova, O. V. ^{[1
]}

Sobenina, L. N. ^{[1
]}

机构：

[1] Russian Acad Sci, Siberian Branch, AE Favorsky Irkutsk Inst Chem, Irkutsk 664033, Russia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2012年 / 47卷 / 11期

关键词：

acetylene; acetophenone oxime; 2-phenylpyrrole; DERIVATIVES; ARYLATION;

D O I：

10.1007/s10593-012-0922-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have developed a technologically orientated, one-pot way of synthesis of high purity 2-phenylpyrrole in 74% yield by treatment of acetophenone oxime with acetylene in the KOH-DMSO system. The reaction is carried out at 135-150 degrees C under an acetylene atmospheric pressure. The synthesis was performed in laboratory (glass apparatus) and in a large scale (10 l reaction vessel).

引用

页码：1367 / 1371

页数：5

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