Reactions of alkyl radicals with oxime ether:: One-pot synthesis of α-amino acids

被引：51

作者：

Miyabe, H ^{[1
]}

Ueda, M ^{[1
]}

Yoshioka, N ^{[1
]}

Yamakawa, K ^{[1
]}

Naito, T ^{[1
]}

机构：

[1] Kobe Pharmaceut Univ, Higashinada Ku, Kobe, Hyogo 6588558, Japan

来源：

TETRAHEDRON | 2000年 / 56卷 / 16期

关键词：

radical addition; oxime ether; atom-transfer; one-pot; alpha-amino acids;

D O I：

10.1016/S0040-4020(00)00119-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The addition of water-resistant carbon radicals to glyoxylic oxime ether provided a new method for the one-pot synthesis of alpha-amino acids via a carbon-carbon bond formation. The reaction of 2-hydroxy-2-methoxyacetic acid methyl ester with benzyloxyamine and an alkyl radical gave the protected alpha-amino acids via the stannyl radical-mediated reaction. In the absence of Bu3SnH, the predominant formation of the desired alkylated products was also observed by using RT and Et3B in boiling toluene. Et2Zn could serve as an initiator of these radical reactions as well as Et3B. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2413 / 2420

页数：8

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