Synthesis of trifluoromethylated pyrrolidines via decarboxylative [3+2] cycloaddition of non-stabilized N-unsubstituted azomethine ylides

被引：10

作者：

Zhang, Xiaofeng ^{[1
,2
]}

Liu, Miao ^{[1
,2
]}

Zhang, Wensheng ^{[3
]}

Legris, Marc ^{[1
,2
]}

Zhang, Wei ^{[1
,2
]}

机构：

[1] Univ Massachusetts, Dept Chem, 100 Morrissey Blvd, Boston, MA 02125 USA

[2] Univ Massachusetts, Ctr Green Chem, 100 Morrissey Blvd, Boston, MA 02125 USA

[3] Jiaozuo Teachers Coll, Sch Sci, 998 Shanyang Rog, Jiaozuo 454100, Peoples R China

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2017年 / 204卷

关键词：

3+2] Cycloaddition; Nonstabilized N-unsubstituted azomethine ylides; Decarboxylative; Trifluoromethyl; Pyrrolidines; ALPHA-AMINO-ACIDS; 1,3-DIPOLAR CYCLOADDITION; FLUORINE;

D O I：

10.1016/j.jfluchem.2017.10.003

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new method for synthesis of trifluoromethylated and pyrrolidinedione-fused pyrrolidines is developed through a three-component and decarboxylative [3 + 2] cycloaddition of non-stabilized N-unsubstituted azomethine ylides with commercially available trifluoroacetophenones. This efficient and economic synthesis only produces stoichiometric amount of CO2 and H2O as byproducts.

引用

页码：18 / 22

页数：5

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