Recent Progress in the Synthesis of 5-Unsubstituted Pyrrolidines via [3+2] Cycloadditions

被引：27
|
作者：
Li, Jundong
Zhao, Huaibo
Zhang, Yandong [1 ]
机构：
[1] Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China
来源：
SYNLETT | 2015年 / 26卷 / 20期
关键词：
cycloaddition; heterocycles; asymmetric catalysis; ylides; alkaloids; ASYMMETRIC 1,3-DIPOLAR CYCLOADDITION; TRACELESS ACTIVATION GROUP; AZOMETHINE YLIDES; ELECTROORGANIC CHEMISTRY; REDUCTIVE DECYANATION; CARBOXYLIC-ACIDS; BOROHYDRIDE; DIBORANE;
D O I：
10.1055/s-0035-1560178
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The 1,3-dipolar cycloaddition of azomethine ylides with alkenes is one of the most powerful methods for the synthesis of multisubstituted pyrrolidines. 5-Unsubstituted pyrrolidines are important structural motifs of numerous biologically active natural products and drugs. Herein, recent progress in the synthesis of 5-unsubstituted pyrrolidines through intermolecular [3+2] cycloaddition is highlighted. 1 Introduction 2 Recent Development with -Silylimines as Azomethine Ylide Precursors 3 Two-Step Protocol with -Iminonitriles as Azomethine Ylide Precursors 4 Applications to Total Synthesis 5 Summary
引用
收藏
页码：2745 / 2750
页数：6
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