Effect of phospholipid membrane on conformation of retro-sequence amyloid-β-peptide 35-25 and normal amyloid-β-peptide 25-35

被引：0
|
作者：
Kodaka, M [1 ]
机构：
[1] Natl Inst Adv Ind Sci & Technol, Tsukuba Ctr, Inst Mol & Cell Biol, Tsukuba, Ibaraki 3058566, Japan
来源：
PROTEIN AND PEPTIDE LETTERS | 2001年 / 8卷 / 05期
关键词：
D O I：
10.2174/0929866013409274
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Negatively-charged phospholipid membrane does not affect the random coil conformation of a non-neurotoxic amyloid-beta -peptide having a retro-sequence 35-25 (A beta 35-25), whereas it changes the conformation of a neurotoxic normal-sequence peptide A beta 25-35 from a random coil to a beta -sheet-like structure under the same condition. The formation of the ordered structure seems to be closely related to the expression of neurotoxicity.
引用
收藏
页码：395 / 398
页数：4
相关论文
共 50 条
  • [1] Effects of solvent on the structure of the Alzheimer amyloid-β(25-35) peptide
    Wei, Guanghong
    Shea, Joan-Emma
    [J]. BIOPHYSICAL JOURNAL, 2006, 91 (05) : 1638 - 1647
  • [2] Prevention of fibrillation of the amyloid-β (25-35) peptide by graphene oxide
    Bag, Sudipta
    DasGupta, Sunando
    Dasgupta, Swagata
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 253
  • [3] The Amyloid-β42 Proxy, Amyloid-β25-35, Induces Normal Human Cerebral Astrocytes to Produce Amyloid-β42
    Dal Pra, Ilaria
    Whitfileld, James F.
    Pacchiana, Raffaella
    Bonafini, Clara
    Talacchi, Andrea
    Chakravarthy, Balu
    Armato, Ubaldo
    Chiarini, Anna
    [J]. JOURNAL OF ALZHEIMERS DISEASE, 2011, 24 (02) : 335 - 347
  • [4] Role of β-Hairpin Formation in Aggregation: The Self-Assembly of the Amyloid-β(25-35) Peptide
    Larini, Luca
    Shea, Joan-Emma
    [J]. BIOPHYSICAL JOURNAL, 2012, 103 (03) : 576 - 586
  • [5] Amyloid-β-peptide 25-35 fragment modulates the expression of the mitochondrial cytochrome oxidase gene
    Han, BG
    Han, EH
    Ahn, JY
    Park, J
    [J]. HEALTHY AGING FOR FUNCTIONAL LONGEVITY: MOLECULAR AND CELLULAR INTERACTIONS IN SENESCENCE, 2001, 928 : 346 - 346
  • [6] Structural diversity of dimers of the Alzheimer amyloid-β(25-35) peptide and polymorphism of the resulting fibrils
    Wei, Guanghong
    Jewett, Andrew I.
    Shea, Joan-Emma
    [J]. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2010, 12 (14) : 3622 - 3629
  • [7] Effects of amyloid-β peptide Aβ25-35 on glycolytic and antioxidant enzymes in erythrocytes of different ages
    Tikhonova, L. A.
    Kaminskii, Yu. G.
    Kosenko, E. A.
    [J]. BIOLOGY BULLETIN, 2014, 41 (04) : 312 - 317
  • [8] In vitro degradation of β-amyloid[25-35] peptide
    Jost, K
    Varga, J
    Penke, S
    Zarándi, M
    [J]. PROTEIN AND PEPTIDE LETTERS, 2001, 8 (06): : 423 - 428
  • [9] THE INFLUENCE OF RADICAL FORMATION ON THE CONFORMATION OF THE AMYLOID β PEPTIDE FRAGMENT (25-35)
    Lovas, S.
    Owen, M. C.
    Marai, C. N. J.
    Borics, A.
    Murphy, R. F.
    [J]. JOURNAL OF PEPTIDE SCIENCE, 2004, 10 : 227 - 227
  • [10] The influence of radical formation on the conformation of the amyloid β peptide fragment (25-35)
    Lovas, Sandor
    Marai, Christopher N. J.
    Borics, Attila
    Murphy, Richard F.
    [J]. PEPTIDES 2004, PROCEEDINGS: BRIDGES BETWEEN DISCIPLINES, 2005, : 744 - 745
12345