In vitro degradation of β-amyloid[25-35] peptide

被引：1

作者：

Jost, K ^{[1
]}

Varga, J ^{[1
]}

Penke, S ^{[1
]}

Zarándi, M ^{[1
]}

机构：

[1] Univ Szeged, Fac Med, Dept Med Chem, H-6720 Szeged, Hungary

来源：

PROTEIN AND PEPTIDE LETTERS | 2001年 / 8卷 / 06期

关键词：

D O I：

10.2174/0929866013409076

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Some amyloid-derived peptides show their toxic effects only after a long "aging" period performed several days at pH 7.4 and 37 degreesC far cluster formation. Our experiments show that long aging of beta -amyloid[25-35] under physiological conditions results in peptide band cleavage between Asn(27) and Lys(28). Relatively short incubation time (24 hours) and absence of Ca2+ ions prevent peptide cleavage and results in good aggregation of beta -amyloids.

引用

页码：423 / 428

页数：6

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