In vitro degradation of β-amyloid[25-35] peptide

被引：1
|
作者：
Jost, K [1 ]
Varga, J [1 ]
Penke, S [1 ]
Zarándi, M [1 ]
机构：
[1] Univ Szeged, Fac Med, Dept Med Chem, H-6720 Szeged, Hungary
来源：
PROTEIN AND PEPTIDE LETTERS | 2001年 / 8卷 / 06期
关键词：
D O I：
10.2174/0929866013409076
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Some amyloid-derived peptides show their toxic effects only after a long "aging" period performed several days at pH 7.4 and 37 degreesC far cluster formation. Our experiments show that long aging of beta -amyloid[25-35] under physiological conditions results in peptide band cleavage between Asn(27) and Lys(28). Relatively short incubation time (24 hours) and absence of Ca2+ ions prevent peptide cleavage and results in good aggregation of beta -amyloids.
引用
收藏
页码：423 / 428
页数：6
相关论文
共 50 条
  • [41] Interaction of the β amyloid - Aβ(25-35) - peptide with zwitterionic and negatively charged vesicles with and without cholesterol
    Singh, Jasmeet
    Peric, Miroslav
    [J]. CHEMISTRY AND PHYSICS OF LIPIDS, 2018, 216 : 39 - 47
  • [42] β-amyloid peptide (25-35) as a tool for in vivo modelling Alzheimer's disease in rats
    Stepanichev, MY
    Onufriev, MV
    Moiseeva, YV
    Lazareva, NA
    Alessenko, AV
    Victorov, IV
    Gulyaeva, NV
    [J]. JOURNAL OF NEUROCHEMISTRY, 2001, 77 : 19 - 19
  • [43] Spectroscopic investigation of Ginkgo biloba terpene trilactones and their interaction with amyloid peptide Aβ(25-35)
    He, Jiangtao
    Petrovic, Ana G.
    Dzyuba, Sergei V.
    Berova, Nina
    Nakanishi, Koji
    Polavarapu, Prasad L.
    [J]. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2008, 69 (04) : 1213 - 1222
  • [44] Central administration of amyloid β-peptide (25-35) and individual features of cognitive behavior in rats
    Mugantseva E.A.
    Podolskii I.Ya.
    [J]. Neuroscience and Behavioral Physiology, 2010, 40 (9) : 964 - 968
  • [45] Electron microscopic study of the effect of fullerene on the formation of amyloid fibrils by the Aβ25-35 peptide
    Podlubnaya Z.A.
    Podol'Skii I.Ya.
    Shpagina M.D.
    Marsagishvili L.G.
    [J]. Biophysics, 2006, 51 (5) : 701 - 704
  • [46] Central Administration of the Amyloid β-peptide (25-35) and Individual Features of Cognitive Behavior of Rats
    Mugantseva, E. A.
    Podolski, I. Ya.
    [J]. ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA, 2009, 59 (05) : 616 - 621
  • [47] Electron microscopic study of the influence of fullerene on the formation of amyloid fibrils by Aβ25-35 peptide
    Podlubnaya, Z. A.
    Podolski, I. Ya.
    Shpagina, M. D.
    Marsagishvili, L. G.
    [J]. BIOFIZIKA, 2006, 51 (05): : 795 - 798
  • [48] Comparison of the structures of β amyloid peptide (25-35) and substance P in trifluoroethanol/water solution
    Lee, S
    Suh, YH
    Kim, S
    Kim, Y
    [J]. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 1999, 17 (02): : 381 - 391
  • [49] Structure of Aβ(25-35) peptide in different environments
    Shanmugam, G
    Polavarapu, PL
    [J]. BIOPHYSICAL JOURNAL, 2004, 87 (01) : 622 - 630
  • [50] Amyloid Beta 25-35 induces blood-brain barrier disruption in vitro
    Cuevas, Elvis
    Rosas-Hernandez, Hector
    Burks, Susan M.
    Ramirez-Lee, Manuel A.
    Guzman, Aida
    Imam, Syed Z.
    Ali, Syed F.
    Sarkar, Sumit
    [J]. METABOLIC BRAIN DISEASE, 2019, 34 (05) : 1365 - 1374
12345