Effect of β-amyloid peptide fragment 25-35 on nonselective permeability of mitochondria

被引：42
|
作者：
Shevtzova, EF [1 ]
Kireeva, EG [1 ]
Bachurin, SO [1 ]
机构：
[1] Russian Acad Sci, Inst Physiol Act Subst, Neurochem Lab, Chernogolovka 142432, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2001年 / 132卷 / 06期
关键词：
mitochondria; beta-amyloid; neurodegeneration; cyclosporine-sensitive mitochondrial channels; lipid peroxidation;
D O I：
10.1023/A:1014559331402
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
beta-Amyloid peptide fragment 25-35 potentiated phosphate- and calcium-induced opening of mitochondrial channels and caused swelling of mitochondria (even without exogenous calcium and phosphate). These changes were accompanied by accumulation of lipid peroxidation products in mitochondria. Specific inhibitors of mitochondrial channels ADP and cyclosporine A prevented beta-amyloid peptide-induced swelling of mitochondria. Our findings suggest that potentiation of mitochondrial channel opening is an important component of the neurodegenerative effect of beta-amyloid.
引用
收藏
页码：1173 / 1176
页数：4
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