Effects of amyloid-β peptide Aβ25-35 on glycolytic and antioxidant enzymes in erythrocytes of different ages

被引：2
|
作者：
Tikhonova, L. A. [1 ,2 ]
Kaminskii, Yu. G. [1 ]
Kosenko, E. A. [1 ,2 ]
机构：
[1] Russian Acad Sci, Inst Theoret & Expt Biophys, Pushchino 142290, Moscow Oblast, Russia
[2] Pushchino State Inst Nat Sci, Pushchino 142290, Moscow Oblast, Russia
来源：
BIOLOGY BULLETIN | 2014年 / 41卷 / 04期
关键词：
RED-BLOOD-CELLS; LIFE-SPAN; AMMONIA INTOXICATION; GLUTATHIONE; SEPARATION; PROTEIN; RATS;
D O I：
10.1134/S1062359014040116
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Amyloid-beta peptide A beta(25-35) was shown to cause lysis of rat erythrocytes of different ages. The toxicity of A beta(25-35) positively correlated with both the erythrocyte age and the peptide concentration. The activity of glycolytic, antioxidant, and Na+/K+-ATPase enzymes decreased with erythrocyte aging in vivo. In vitro A beta(25-35) reduced the activity of hexokinase, phosphofructokinase, pyruvate kinase, glutathione peroxidase, and glutathione transferase and increased Na+/K+-ATPase activity in aged erythrocytes to a greater degree than in young cells.
引用
收藏
页码：312 / 317
页数：6
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