Polycyclic N-Heterocyclic Compounds. Part 84: Reaction of N-(pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-yl)amidines or N-(pyrido[2′,3′:4,5]furo[3,2-d]pyrimidin-4-yl)amidines with Hydroxylamine Hydrochloride

被引：4

作者：

Okuda, Kensuke ^{[1
]}

Ide, Ryota ^{[2
]}

Uramaru, Naoto ^{[2
]}

Hirota, Takashi ^{[2
]}

机构：

[1] Gifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, Japan

[2] Okayama Univ, Fac Pharmaceut Sci, Lab Pharmaceut Chem, Kita Ku, Okayama 7008530, Japan

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2015年 / 52卷 / 03期

关键词：

N-(QUINAZOLIN-4-YL)AMIDINE DERIVATIVES;

D O I：

10.1002/jhet.2033

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reactions of nine N-(pyrido[3,2:4,5]thieno[3,2-d]pyrimidin-4-yl)amidines (3) with hydroxylamine hydrochloride produced new cyclization products. These were formed via ring cleavage of the pyrimidine component followed by a 1,2,4-oxadiazole-forming ring closure to give N-[2-([1,2,4]oxadiazol-5-yl)thieno[2,3-b]pyridin-3-yl]formamide oximes (11). Reaction of six N-(pyrido[2,3:4,5]furo[3,2-d]pyrimidin-4-yl)amidines (12) with hydroxylamine hydrochloride gave similar results. Effects of the newly synthesized compounds on pentosidine formation were also evaluated.

引用

页码：880 / 887

页数：8

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