Synthesis of 4-(Thieno [3, 2-d] pyrimidin-4-yl) Morpholine

被引：0
|
作者：
Lei, Huajun [1 ]
Wang, Linxiao [1 ]
Xiong, Yingjia [1 ]
Lan, Zhou [1 ]
机构：
[1] Jiangxi Sci & Technol Normal Univ, Sch Pharm, Nanchang 330013, Jiangxi, Peoples R China
来源：
PROCEEDINGS OF THE 2016 7TH INTERNATIONAL CONFERENCE ON EDUCATION, MANAGEMENT, COMPUTER AND MEDICINE (EMCM 2016) | 2017年 / 59卷
关键词：
4-(Thieno[3,2-d]pyrimidin-4-yl)morpholine; Synthesis; Intermediate;
D O I：
暂无
中图分类号：
F [经济];
学科分类号：
02 ;
摘要：
4-(Thieno[3,2-d]pyrimidin-4-yl)morpholine derivatives is an important intermediate which inhibited tumor necrosis factor alpha and nitric oxide. In this work, a rapid and green synthetic method for compound (5) was established. The compound (5) was synthesized from the commercially available methyl 3-aminothiophene-2-carboxylate and formamidine acetate through three steps including condensation reaction, chlorination, and nucleophilic substitution. The structure was confirmed by H NMR and MS. Furthermore, the total yield of the three steps was 43%.
引用
收藏
页码：599 / 602
页数：4
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