Synthesis of 4-(Thieno [3, 2-d] pyrimidin-4-yl) Morpholine

被引：0

作者：

Lei, Huajun ^{[1
]}

Wang, Linxiao ^{[1
]}

Xiong, Yingjia ^{[1
]}

Lan, Zhou ^{[1
]}

机构：

[1] Jiangxi Sci & Technol Normal Univ, Sch Pharm, Nanchang 330013, Jiangxi, Peoples R China

来源：

PROCEEDINGS OF THE 2016 7TH INTERNATIONAL CONFERENCE ON EDUCATION, MANAGEMENT, COMPUTER AND MEDICINE (EMCM 2016) | 2017年 / 59卷

关键词：

4-(Thieno[3,2-d]pyrimidin-4-yl)morpholine; Synthesis; Intermediate;

D O I：

暂无

中图分类号：

F [经济];

学科分类号：

02 ;

摘要：

4-(Thieno[3,2-d]pyrimidin-4-yl)morpholine derivatives is an important intermediate which inhibited tumor necrosis factor alpha and nitric oxide. In this work, a rapid and green synthetic method for compound (5) was established. The compound (5) was synthesized from the commercially available methyl 3-aminothiophene-2-carboxylate and formamidine acetate through three steps including condensation reaction, chlorination, and nucleophilic substitution. The structure was confirmed by H NMR and MS. Furthermore, the total yield of the three steps was 43%.

引用

页码：599 / 602

页数：4

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