Polycyclic N-Heterocyclic Compounds. Part 84: Reaction of N-(pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-yl)amidines or N-(pyrido[2′,3′:4,5]furo[3,2-d]pyrimidin-4-yl)amidines with Hydroxylamine Hydrochloride

被引：4
|
作者：
Okuda, Kensuke [1 ]
Ide, Ryota [2 ]
Uramaru, Naoto [2 ]
Hirota, Takashi [2 ]
机构：
[1] Gifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, Japan
[2] Okayama Univ, Fac Pharmaceut Sci, Lab Pharmaceut Chem, Kita Ku, Okayama 7008530, Japan
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2015年 / 52卷 / 03期
关键词：
N-(QUINAZOLIN-4-YL)AMIDINE DERIVATIVES;
D O I：
10.1002/jhet.2033
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reactions of nine N-(pyrido[3,2:4,5]thieno[3,2-d]pyrimidin-4-yl)amidines (3) with hydroxylamine hydrochloride produced new cyclization products. These were formed via ring cleavage of the pyrimidine component followed by a 1,2,4-oxadiazole-forming ring closure to give N-[2-([1,2,4]oxadiazol-5-yl)thieno[2,3-b]pyridin-3-yl]formamide oximes (11). Reaction of six N-(pyrido[2,3:4,5]furo[3,2-d]pyrimidin-4-yl)amidines (12) with hydroxylamine hydrochloride gave similar results. Effects of the newly synthesized compounds on pentosidine formation were also evaluated.
引用
收藏
页码：880 / 887
页数：8
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