ONE-POT SYNTHESIS OF TRISUBSTITUTED PYRAZOLES VIA MULTICOMPONENT APPROACH

被引：17
|
作者：
Santhosh, P. [1 ]
Chunduru, V. S. R. [1 ]
Rao, V. Rajeswar [1 ]
机构：
[1] Natl Inst Technol, Dept Chem, Warangal 506004, Andhra Pradesh, India
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2011年 / 47卷 / 04期
关键词：
acetylacetone; 3-(2-bromoacetyl)coumarins; hydrazine hydrate; phenacyl bromides; pyrazole; one-pot; multicomponent reactions; DERIVATIVES;
D O I：
10.1007/s10593-011-0779-z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient one-pot multicomponent reaction for the synthesis of 1-aryl- or 1-heteryl-substituted 3,5-dimethylpyrazoles with excellent yields has been described. Reaction of 3-(2-bromoacetyl)coumarins or phenacyl bromides with acetylacetone and hydrazine hydrate in ethanol afforded the corresponding 3,5-dimethylpyrazoles in good yields. All the synthesized compounds were characterized by their analytical and spectral data.
引用
收藏
页码：448 / 451
页数：4
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