Copper-Catalyzed One-Pot Multicomponent Reactions: Synthesis of 4-Arylsulfenyl Pyrazoles

被引：9

作者：

Oliveira, Daniela H. ^{[1
]}

Alves, Diego ^{[1
]}

Jacob, Raquel G. ^{[1
]}

Xavier, Maurcio C. D. F. ^{[1
]}

机构：

[1] Univ Fed Pelotas, CCQFA, LASOL, BR-96010900 Pelotas, RS, Brazil

来源：

CURRENT ORGANIC SYNTHESIS | 2015年 / 12卷 / 06期

关键词：

Catalysis; copper; green chemistry; heterocycles; multicomponent; pyrazoles; sulfur; C-H BOND; ROOM-TEMPERATURE SYNTHESIS; BIOLOGICAL EVALUATION; SOLVENT-FREE; 1,3-DIPOLAR CYCLOADDITION; AZIDOPHENYL ARYLSELENIDES; POLYFUNCTIONAL PYRAZOLES; 3-COMPONENT SYNTHESIS; RECEPTOR ANTAGONISTS; DIRECT THIOLATION;

D O I：

10.2174/157017941206150828114009

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe here a simple protocol for the synthesis of 4-(arylsulfenyl)-1H-pyrazoles by copper-catalyzed cyclocondensation and direct C-H bond sulfenylation reactions. The products were obtained in good yields by the reaction of a range of 1,3-diketones, arylhydrazines and arylthiols, using catalytic amount of CuI. This One-Pot Multicomponent protocol is an efficient method to synthesize new compounds with potential application in biological studies and material sciences.

引用

页码：822 / 829

页数：8

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