In vitro Investigation of the Antimicrobial Activity of a Series of Lipophilic Phenols and Naphthols

被引：5

作者：

Govender, Thavendran ^{[1
]}

Govinden, Usha ^{[1
]}

Mocktar, Chunderika ^{[1
]}

Kruger, Hendrik G. ^{[1
]}

Veljkovic, Jelena ^{[2
]}

Cindro, Nikola ^{[2
]}

Bobinac, Damir ^{[2
]}

Zabcic, Ivana ^{[2
]}

Mlinaric-Majerski, Kata ^{[2
]}

Basaric, Nikola ^{[2
]}

机构：

[1] Univ KwaZulu Natal, Sch Hlth Sci, Catalysis & Peptide Res Unit, Durban, South Africa

[2] Rudjer Boskovic Inst, Dept Organ Chem & Biochem, Bijenicka Cesta 54, Zagreb 10000, Croatia

来源：

SOUTH AFRICAN JOURNAL OF CHEMISTRY-SUID-AFRIKAANSE TYDSKRIF VIR CHEMIE | 2016年 / 69卷

基金：

新加坡国家研究基金会;

关键词：

Antimicrobial activity; phenols; naphthols; quinone methides; PHENETHYL ALCOHOL; ESCHERICHIA-COLI; ANTIBACTERIAL ACTIVITY; QUINONE METHIDES; DERIVATIVES; PHOTODEHYDRATION; PERMEABILITY; CHEMISTRY; EXTRACTS; GROWTH;

D O I：

10.17159/0379-4350/2016/v69a6

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Five groups of phenols/naphthols (42 compounds in total) were synthesized and screened against Gram-positive Staphylococcus aureus and Bacillus subtilis, Gram-negative Escherichia coli and Klebsiella pneumoniae, and the fungus Candida albicans. Whereas compounds were found inactive against Gram-negative bacteria, potent activities against Gram-positive bacteria were observed. The activities correlate with the ability of molecules to form quinone methides, suggesting potential new modes of action.

引用

页码：44 / +

页数：11

共 50 条

[41] Synthesis and biological activity of lipophilic analogs of the cationic antimicrobial active peptide anoplin
Chionis, Kostas
Krikorian, Dimitrios
Koukkou, Anna-Irini
Sakarellos-Daitsiotis, Maria
Panou-Pomonis, Eugenia
JOURNAL OF PEPTIDE SCIENCE, 2016, 22 (11-12) : 731 - 736
[42] Contribution to investigation of antimicrobial activity of styrylquinolines
Cieslik, Wioleta
Musiol, Robert
Nycz, Jacek E.
Jampilek, Josef
Vejsova, Marcela
Wolff, Mariusz
Machura, Barbara
Polanski, Jaroslaw
BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 20 (24) : 6960 - 6968
[43] In Vitro Antimicrobial Activity Screening of Ethanol Extract of Lavandula stoechas and Investigation of Its Biochemical Composition
Canli, Kerem
Yetgin, Ali
Benek, Atakan
Bozyel, Mustafa Eray
Altuner, Ergin Murat
ADVANCES IN PHARMACOLOGICAL SCIENCES, 2019, 2019
[44] Investigation of the antimicrobial and anticancer activity of aminonaphthoquinones
Wellington, Kevin W.
Kolesnikova, Natasha I.
Nyoka, Nomgqibelo B. P.
McGaw, Lyndy J.
DRUG DEVELOPMENT RESEARCH, 2019, 80 (01) : 138 - 146
[45] Antimicrobial activity of a new series of benzimidazole derivatives
Yusuf Özkay
Yağmur Tunalı
Hülya Karaca
İlhan Işıkdağ
Archives of Pharmacal Research, 2011, 34 : 1427 - 1435
[46] SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF A SERIES OF CAESPITIN DERIVATIVES
VANDERSCHYF, CJ
DEKKER, TG
FOURIE, TG
SNYCKERS, FO
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 30 (03) : 375 - 381
[47] Antimicrobial Activity of a New Series of Benzimidazole Derivatives
Ozkay, Yusuf
Tunali, Yagmur
Karaca, Hulya
Isikdag, Ilhan
ARCHIVES OF PHARMACAL RESEARCH, 2011, 34 (09) : 1427 - 1435
[48] Selected in vitro methods to determine antioxidant activity of hydrophilic/lipophilic substances
Acsova, Aneta
Martiniakova, Silvia
Hojerova, Jarmila
ACTA CHIMICA SLOVACA, 2019, 12 (02): : 200 - 211
[49] Synthesis and in vitro antiviral activity of lipophilic pyrimidine nucleoside/carborane conjugates
Bialek-Pietras, Magdalena
Olejniczak, Agnieszka B.
Paradowska, Edyta
Studzinska, Miroslawa
Suski, Patrycja
Jablonska, Agnieszka
Lesnikowski, Zbigniew J.
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2015, 798 : 99 - 105
[50] Synthesis, In Silico and In Vitro Cytostatic Activity of New Lipophilic Derivatives of Hydroxyurea
Khansefid, Zeynab
Davood, Asghar
Iman, Maryam
Fasihi, Mandi
RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY, 2018, 13 (03) : 378 - 385

← 1 2 3 4 5 →