In vitro Investigation of the Antimicrobial Activity of a Series of Lipophilic Phenols and Naphthols

被引：5

作者：

Govender, Thavendran ^{[1
]}

Govinden, Usha ^{[1
]}

Mocktar, Chunderika ^{[1
]}

Kruger, Hendrik G. ^{[1
]}

Veljkovic, Jelena ^{[2
]}

Cindro, Nikola ^{[2
]}

Bobinac, Damir ^{[2
]}

Zabcic, Ivana ^{[2
]}

Mlinaric-Majerski, Kata ^{[2
]}

Basaric, Nikola ^{[2
]}

机构：

[1] Univ KwaZulu Natal, Sch Hlth Sci, Catalysis & Peptide Res Unit, Durban, South Africa

[2] Rudjer Boskovic Inst, Dept Organ Chem & Biochem, Bijenicka Cesta 54, Zagreb 10000, Croatia

来源：

SOUTH AFRICAN JOURNAL OF CHEMISTRY-SUID-AFRIKAANSE TYDSKRIF VIR CHEMIE | 2016年 / 69卷

基金：

新加坡国家研究基金会;

关键词：

Antimicrobial activity; phenols; naphthols; quinone methides; PHENETHYL ALCOHOL; ESCHERICHIA-COLI; ANTIBACTERIAL ACTIVITY; QUINONE METHIDES; DERIVATIVES; PHOTODEHYDRATION; PERMEABILITY; CHEMISTRY; EXTRACTS; GROWTH;

D O I：

10.17159/0379-4350/2016/v69a6

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Five groups of phenols/naphthols (42 compounds in total) were synthesized and screened against Gram-positive Staphylococcus aureus and Bacillus subtilis, Gram-negative Escherichia coli and Klebsiella pneumoniae, and the fungus Candida albicans. Whereas compounds were found inactive against Gram-negative bacteria, potent activities against Gram-positive bacteria were observed. The activities correlate with the ability of molecules to form quinone methides, suggesting potential new modes of action.

引用

页码：44 / +

页数：11

共 50 条

[11] In vitro antimicrobial activity of a new series of 1,4-naphthoquinones
Riffel, A
Medina, LF
Stefani, V
Santos, RC
Bizani, D
Brandelli, A
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2002, 35 (07) : 811 - 818
[12] Antimicrobial Activity of Lipophilic Avian Eggshell Surface Extracts
Wellman-Labadie, Olivier
Lemaire, Simon
Mann, Karlheinz
Picman, Jaroslav
Hincke, Maxwell T.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2010, 58 (18) : 10156 - 10161
[13] MODELS FOR INVESTIGATION OF STRUCTURE-ACTIVITY RELATIONSHIP IN A SERIES OF ANTIMICROBIAL COMPOUNDS
DROBNICA, L
NEMEC, P
AUGUSTIN, J
FOLIA MICROBIOLOGICA, 1971, 16 (06) : 494 - &
[14] In Vitro Investigation of Some Plant Essential Oils for Potential Antimicrobial Activity
Ivopol, Maria
Vlasceanu, Gabriela
Dune, Alina
Popa, Marcela
Marutescu, Luminita
Ionescu, Daniela
Ivopol, Gabriel-Calin
Crisan, Iuliana
Chifiriuc, Carmen
PROCEEDINGS OF THE ROMANIAN NATIONAL CONGRESS OF PHARMACY, 17TH EDITION: 21ST CENTURY PHARMACY - BETWEEN INTELLIGENT SPECIALIZATION AND SOCIAL RESPONSIBILITY, 2018, : 98 - 106
[15] In vitro investigation of cytotoxicity and antimicrobial activity of silver/alginate nanocomposite microbeads
Jovanovic, Z.
Stojkovska, J.
Vukasinovic-Sekulic, M.
Matic, I.
Juranic, Z.
Obradovic, B.
Miskovic-Stankovic, V.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2012, 6 : 218 - 218
[16] INHIBITION OF HUMAN-PLATELET LIPOXYGENASE AND SHEEP SEMINAL VESICULAR CYCLOOXYGENASE BY A SERIES OF SUBSTITUTED PHENOLS AND NAPHTHOLS
TOBIAS, LD
HAMILTON, JG
DEWHIRST, FE
FEDERATION PROCEEDINGS, 1982, 41 (04) : 1078 - 1078
[17] ANTIMICROBIAL ACTIVITY OF SPACE-LIMITED ORGANOSILICON PHENOLS
TUMANOV, AA
GLUKHOVA, MN
FROLOVA, SM
MUSLIN, DV
LYAPINA, NS
OLEINIK, EP
KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1992, 26 (03): : 51 - 53
[18] Novel Lipophilic Jatrorrhizine: Synthesis, Antimicrobial, and Cytotoxic Activity Evaluation
Jiang, Xiaofei
Liu, Yi
Cao, Jianfeng
Xiong, Nanqiang
Zhang, Nengling
Qiu, Shengxiang
LATIN AMERICAN JOURNAL OF PHARMACY, 2017, 36 (10): : 2105 - 2111
[19] Lipophilic analogs of isoniazid with antiproliferative in vitro activity -: VIII
Vigorita, MG
Maccari, R
Ottanà, R
Monforte, F
MEDICINAL CHEMISTRY RESEARCH, 1999, 9 (05) : 306 - 321
[20] Investigation of in vivo radioprotective and in vitro antioxidant and antimicrobial activity of garlic (Allium Sativum)
Batcioglu, K.
Yilmaz, Z.
Satilmis, B.
Uyumlu, A. B.
Erkal, H. S.
Yucel, N.
Gunal, S.
Serin, M.
Demirtas, H.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2012, 16 : 47 - 57

← 1 2 3 4 5 →