In vitro Investigation of the Antimicrobial Activity of a Series of Lipophilic Phenols and Naphthols

被引：5

作者：

Govender, Thavendran ^{[1
]}

Govinden, Usha ^{[1
]}

Mocktar, Chunderika ^{[1
]}

Kruger, Hendrik G. ^{[1
]}

Veljkovic, Jelena ^{[2
]}

Cindro, Nikola ^{[2
]}

Bobinac, Damir ^{[2
]}

Zabcic, Ivana ^{[2
]}

Mlinaric-Majerski, Kata ^{[2
]}

Basaric, Nikola ^{[2
]}

机构：

[1] Univ KwaZulu Natal, Sch Hlth Sci, Catalysis & Peptide Res Unit, Durban, South Africa

[2] Rudjer Boskovic Inst, Dept Organ Chem & Biochem, Bijenicka Cesta 54, Zagreb 10000, Croatia

来源：

SOUTH AFRICAN JOURNAL OF CHEMISTRY-SUID-AFRIKAANSE TYDSKRIF VIR CHEMIE | 2016年 / 69卷

基金：

新加坡国家研究基金会;

关键词：

Antimicrobial activity; phenols; naphthols; quinone methides; PHENETHYL ALCOHOL; ESCHERICHIA-COLI; ANTIBACTERIAL ACTIVITY; QUINONE METHIDES; DERIVATIVES; PHOTODEHYDRATION; PERMEABILITY; CHEMISTRY; EXTRACTS; GROWTH;

D O I：

10.17159/0379-4350/2016/v69a6

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Five groups of phenols/naphthols (42 compounds in total) were synthesized and screened against Gram-positive Staphylococcus aureus and Bacillus subtilis, Gram-negative Escherichia coli and Klebsiella pneumoniae, and the fungus Candida albicans. Whereas compounds were found inactive against Gram-negative bacteria, potent activities against Gram-positive bacteria were observed. The activities correlate with the ability of molecules to form quinone methides, suggesting potential new modes of action.

引用

页码：44 / +

页数：11

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