In vitro antitubercular activity of extract and constituents from the stem bark of Disthemonanthus benthamianus

被引：12
|
作者：
Evina, Jean Noel [1 ]
Bikobo, Dominique Serge Ngono [1 ,5 ]
Zintchem, Auguste Abouem A. [1 ,2 ]
Nyemeck, Norbert Mbabi, II [1 ,3 ]
Ndedi, Esther Del Florence Moni [4 ]
Diboue, Patrick Herve Betote [4 ]
Nyegue, Maximilienne Ascension [4 ]
Atchade, Alex de Theodore [1 ]
Pegnyemb, Dieudonne Emmanuel [1 ]
Koert, Ulrich
Bochet, Christian G. [5 ]
机构：
[1] Univ Yaounde I, Dept Organ Chem, Fac Sci, Yaounde, Cameroon
[2] Univ Yaounde I, Dept Chem, Higher Training Coll, Yaounde, Cameroon
[3] Philipps Univ Marburg, Fac Chem, Marburg, Germany
[4] Univ Yaounde I, Dept Microbiol, Fac Sci, Yaounde, Cameroon
[5] Univ Fribourg, Dept Chem, Fribourg, Switzerland
来源：
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2017年 / 27卷 / 06期
基金：
瑞士国家科学基金会;
关键词：
Fabaceae; Antitubercular activity; Distemonanthoside; Flavonoids; Phenolic acids; AGENTS; PLANTS;
D O I：
10.1016/j.bjp.2017.09.006
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new C-glycosylflavone, apigenin 7-methyl ether 6-C-[beta-xylopyranosyl-(1?3)-beta-glucopyranoside] named distemonanthoside was isolated from the stem bark of Distemonanthus benthamianus Baill., Fabaceae, along with six known compounds, sitosterol 3-O-beta-d-glucopyranoside, 4-methoxygallic acid, syringic acid, quercetin, 6-O-acetylvitexin, quercetin 3-O-beta-d-glucopyranoside. The structures of those compounds and others were determined through spectral analyses. Compounds distemonanthoside, sitosterol 3-O-beta-d-glucopyranoside, 4-methoxygallic acid and quercetin were tested against a clinical isolate strain of Mycobacterium tuberculosis AC 45; they exhibited good to moderate antitubercular activities with MIC values ranged from 31.25 to 125 mu g/ml.(c) 2017 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda.
引用
收藏
页码：739 / 743
页数：5
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