In vitro antitubercular activity of extract and constituents from the stem bark of Disthemonanthus benthamianus

被引：12

作者：

Evina, Jean Noel ^{[1
]}

Bikobo, Dominique Serge Ngono ^{[1
,5
]}

Zintchem, Auguste Abouem A. ^{[1
,2
]}

Nyemeck, Norbert Mbabi, II ^{[1
,3
]}

Ndedi, Esther Del Florence Moni ^{[4
]}

Diboue, Patrick Herve Betote ^{[4
]}

Nyegue, Maximilienne Ascension ^{[4
]}

Atchade, Alex de Theodore ^{[1
]}

Pegnyemb, Dieudonne Emmanuel ^{[1
]}

Koert, Ulrich

Bochet, Christian G. ^{[5
]}

机构：

[1] Univ Yaounde I, Dept Organ Chem, Fac Sci, Yaounde, Cameroon

[2] Univ Yaounde I, Dept Chem, Higher Training Coll, Yaounde, Cameroon

[3] Philipps Univ Marburg, Fac Chem, Marburg, Germany

[4] Univ Yaounde I, Dept Microbiol, Fac Sci, Yaounde, Cameroon

[5] Univ Fribourg, Dept Chem, Fribourg, Switzerland

来源：

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2017年 / 27卷 / 06期

基金：

瑞士国家科学基金会;

关键词：

Fabaceae; Antitubercular activity; Distemonanthoside; Flavonoids; Phenolic acids; AGENTS; PLANTS;

D O I：

10.1016/j.bjp.2017.09.006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new C-glycosylflavone, apigenin 7-methyl ether 6-C-[beta-xylopyranosyl-(1?3)-beta-glucopyranoside] named distemonanthoside was isolated from the stem bark of Distemonanthus benthamianus Baill., Fabaceae, along with six known compounds, sitosterol 3-O-beta-d-glucopyranoside, 4-methoxygallic acid, syringic acid, quercetin, 6-O-acetylvitexin, quercetin 3-O-beta-d-glucopyranoside. The structures of those compounds and others were determined through spectral analyses. Compounds distemonanthoside, sitosterol 3-O-beta-d-glucopyranoside, 4-methoxygallic acid and quercetin were tested against a clinical isolate strain of Mycobacterium tuberculosis AC 45; they exhibited good to moderate antitubercular activities with MIC values ranged from 31.25 to 125 mu g/ml.(c) 2017 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda.

引用

页码：739 / 743

页数：5

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