Multi-pulse generator for electroporation

被引：3
|
作者：
Wu, P [1 ]
Bao, JL [1 ]
Wang, H [1 ]
Wang, HP [1 ]
机构：
[1] Zhejiang Univ, Coll Med, Hangzhou 310006, Peoples R China
来源：
PROCEEDINGS OF THE 25TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-4: A NEW BEGINNING FOR HUMAN HEALTH | 2003年 / 25卷
关键词：
transdermal energy; truncation coefficient; pulse protocol; electroporation;
D O I：
10.1109/IEMBS.2003.1280542
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Purpose: A multi-pulse generator provides a tool for the research of electroporation for transdermal drug delivery. Method: The multi-pulse generator with which capacitor charges and discharges can generate a series pulse that is controlled by a pulse controller, and output of a voltage source in the apparatus is risen from DC 12V of power supply to DC 400 V by a convertor. And it is recorded some graphs of pulse of which applies to skin using Ag-AgCl electrode placed to same side of stratum corneum with the storage capacitance of 2.2 muF, 22 muF, 68 muF and 100 muF, respectively. Results: When truncation coefficient is less than 1/5, the complete exponential decay pulse can be acquired, and skin resistance is 3.57 +/- 0.66 KOmega. Conclusion: The truncation coefficient is restricted by transdermal energy and pulse protocol. If parallel resistance and storage capacitance are optimized designed, it can be obtained that the highest energy efficiency of the power supply and the lowest truncation coefficient of pulse.
引用
收藏
页码：2970 / 2973
页数：4
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