Multi-pulse generator for electroporation

被引：3
|
作者：
Wu, P [1 ]
Bao, JL [1 ]
Wang, H [1 ]
Wang, HP [1 ]
机构：
[1] Zhejiang Univ, Coll Med, Hangzhou 310006, Peoples R China
来源：
PROCEEDINGS OF THE 25TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-4: A NEW BEGINNING FOR HUMAN HEALTH | 2003年 / 25卷
关键词：
transdermal energy; truncation coefficient; pulse protocol; electroporation;
D O I：
10.1109/IEMBS.2003.1280542
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Purpose: A multi-pulse generator provides a tool for the research of electroporation for transdermal drug delivery. Method: The multi-pulse generator with which capacitor charges and discharges can generate a series pulse that is controlled by a pulse controller, and output of a voltage source in the apparatus is risen from DC 12V of power supply to DC 400 V by a convertor. And it is recorded some graphs of pulse of which applies to skin using Ag-AgCl electrode placed to same side of stratum corneum with the storage capacitance of 2.2 muF, 22 muF, 68 muF and 100 muF, respectively. Results: When truncation coefficient is less than 1/5, the complete exponential decay pulse can be acquired, and skin resistance is 3.57 +/- 0.66 KOmega. Conclusion: The truncation coefficient is restricted by transdermal energy and pulse protocol. If parallel resistance and storage capacitance are optimized designed, it can be obtained that the highest energy efficiency of the power supply and the lowest truncation coefficient of pulse.
引用
收藏
页码：2970 / 2973
页数：4
相关论文
共 50 条
  • [31] HEATING OF ELECTRODE SURFACES IN MULTI-PULSE WELDING
    LANKIN, YN
    KASATKIN, OG
    YAVORSKI.YD
    AUTOMATIC WELDING USSR, 1970, 23 (08): : 14 - &
  • [32] Multi-pulse rectifiers with modulation in DC current
    Rolek, Jaroslaw
    PRZEGLAD ELEKTROTECHNICZNY, 2008, 84 (05): : 53 - 57
  • [33] Multi-pulse LPC modeling of articulatory movements
    Bouabana, S
    Maeda, S
    SPEECH COMMUNICATION, 1998, 24 (03) : 227 - 248
  • [34] Enhancement of Optical Wireless Multi-Pulse PPM
    Kozawa, Yusuke
    Habuchi, Hiromasa
    GLOBECOM 2008 - 2008 IEEE GLOBAL TELECOMMUNICATIONS CONFERENCE, 2008,
  • [35] Marine MVDC Multi-Phase Multi-Pulse Supply
    Javaid, Uzair
    Freijedo, Francisco D.
    Dujic, Drazen
    van der Merwe, Wim
    IECON 2017 - 43RD ANNUAL CONFERENCE OF THE IEEE INDUSTRIAL ELECTRONICS SOCIETY, 2017, : 6807 - 6812
  • [36] MICROCALORIMETER SPECTROSCOPY AT HIGH PULSE RATES: A MULTI-PULSE FITTING TECHNIQUE
    Fowler, J. W.
    Alpert, B. K.
    Doriese, W. B.
    Fischer, D. A.
    Jaye, C.
    Joe, Y. I.
    O'Neil, G. C.
    Swetz, D. S.
    Ullom, J. N.
    ASTROPHYSICAL JOURNAL SUPPLEMENT SERIES, 2015, 219 (02):
  • [37] Waveform Control of Multi-Pulse Flat-Top High Magnetic Field Based on Pulsed Generator System
    Xu, Yun
    Li, Peichen
    Lu, Chao
    He, Xiaolong
    Li, Dake
    Fang, Yunchao
    IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY, 2020, 30 (04)
  • [38] The multi-pulse simulation on driving characteristics of AC PDP
    Qu, ML
    Liu, CL
    Sun, J
    He, F
    ISTM/2003: 5TH INTERNATIONAL SYMPOSIUM ON TEST AND MEASUREMENT, VOLS 1-6, CONFERENCE PROCEEDINGS, 2003, : 5025 - 5027
  • [39] Scorpius: The Development of a New Multi-Pulse Radiographic System
    Crawford, Mark
    Barraza, Juan
    2017 IEEE 21ST INTERNATIONAL CONFERENCE ON PULSED POWER (PPC), 2017,
  • [40] Study and Application of Multi-Pulse Composite Perforation Technology
    Cai, Shan
    4TH INTERNATIONAL CONFERENCE ON ENERGY SCIENCE AND APPLIED TECHNOLOGY (ESAT 2018), 2019, 2066
12345