Highly reactive 4-membered ring nitrogen-containing heterocycles: Synthesis and properties

被引：0

作者：

Alcaide, Benito ^{[1
]}

Almendros, Pedro ^{[2
]}

Aragoncillo, Cristina ^{[1
]}

机构：

[1] Univ Complutense Madrid, Dept Quim Organ 1, Grp Lactamas & Heterociclos Bioact, Unidad Asociada CSIC, E-28040 Madrid, Spain

[2] CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain

来源：

CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT | 2010年 / 13卷 / 06期

关键词：

Azetidine; beta-lactam; heterocycle; rearrangement; stereoselectivity; strain; BETA-LACTAMS; BUILDING-BLOCKS; BIOLOGICAL EVALUATION; ASYMMETRIC-SYNTHESIS; STAUDINGER REACTION; KAINIC ACID; KETENES; 2-AZETIDINONES; CYCLOADDITION; INHIBITORS;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

4-Membered nitrogen-containing heterocycles, such as beta-lactams (ie, 2-azetidinones) and azetidines, are useful substrates in organic chemistry for the design and preparation of biologically active compounds by functionalization of the different positions of the ring. In addition, these compounds are versatile building blocks for the synthesis of other types of nitrogen-containing compounds with potential biological properties. This review summarizes recent data regarding the preparation and properties of 4-membered nitrogen-containing heterocyclic rings, as well as their biological activities.

引用

页码：685 / 697

页数：13

共 50 条

[21] Synthesis of oxygen- and nitrogen-containing heterocycles by ring-closing metathesis
Deiters, A
Martin, SF
CHEMICAL REVIEWS, 2004, 104 (05) : 2199 - 2238
[22] The application of azoarenes in the synthesis of nitrogen-containing heterocycles
Halimehjani, Azim Ziyaei
Sadeghzadeh, Nima
Moghaddam, Sina
TETRAHEDRON, 2025, 171
[23] Synthesis of Nitrogen-Containing Heterocycles from Estragole
Smolyak, A. A.
Shklyaev, Yu. V.
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2022, 58 (11) : 1575 - 1580
[24] Fluoroarenes in the synthesis of benzoannulated nitrogen-containing heterocycles
A. A. Layeva
E. V. Nosova
G. N. Lipunova
V. N. Charushin
Russian Chemical Bulletin, 2008, 57 : 947 - 984
[25] Fluoroarenes in the synthesis of benzoannulated nitrogen-containing heterocycles
Layeva, A. A.
Nosova, E. V.
Lipunova, G. N.
Charushin, V. N.
RUSSIAN CHEMICAL BULLETIN, 2008, 57 (05) : 947 - 984
[26] 4-MEMBERED HETEROCYCLES CONTAINING ONE PHOSPHORUS AND ONE OTHER HETEROATOM
AFARINKIA, K
HETEROCYCLES, 1992, 34 (02) : 369 - 385
[27] SYNTHESIS OF NITROGEN-CONTAINING HETEROCYCLES ON COPPER CHROMITE
MEKSS, PA
ANDERSON, AA
SHYMANSKA, MV
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1994, (07): : 950 - 957
[28] Trienamines for the Organocatalytic Synthesis of Nitrogen-Containing Heterocycles
Gutierrez Cano, Jessica R.
Lopez, Julio
Vazquez, Miguel A.
Cruz Cruz, David
Villegas Gomez, Clarisa
CURRENT ORGANIC CHEMISTRY, 2019, 23 (10) : 1078 - 1089
[29] CATALYTIC SYNTHESIS AND TRANSFORMATIONS OF NITROGEN-CONTAINING HETEROCYCLES
LUKEVICS, E
SHIMANSKA, M
LEITIS, L
IOVEL, I
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1994, (11-12): : 1482 - 1509
[30] Tandem Catalysis: Synthesis of Nitrogen-Containing Heterocycles
Campos, Joana F.
Berteina-Raboin, Sabine
CATALYSTS, 2020, 10 (06)

← 1 2 3 4 5 →