Highly reactive 4-membered ring nitrogen-containing heterocycles: Synthesis and properties

被引：0

作者：

Alcaide, Benito ^{[1
]}

Almendros, Pedro ^{[2
]}

Aragoncillo, Cristina ^{[1
]}

机构：

[1] Univ Complutense Madrid, Dept Quim Organ 1, Grp Lactamas & Heterociclos Bioact, Unidad Asociada CSIC, E-28040 Madrid, Spain

[2] CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain

来源：

CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT | 2010年 / 13卷 / 06期

关键词：

Azetidine; beta-lactam; heterocycle; rearrangement; stereoselectivity; strain; BETA-LACTAMS; BUILDING-BLOCKS; BIOLOGICAL EVALUATION; ASYMMETRIC-SYNTHESIS; STAUDINGER REACTION; KAINIC ACID; KETENES; 2-AZETIDINONES; CYCLOADDITION; INHIBITORS;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

4-Membered nitrogen-containing heterocycles, such as beta-lactams (ie, 2-azetidinones) and azetidines, are useful substrates in organic chemistry for the design and preparation of biologically active compounds by functionalization of the different positions of the ring. In addition, these compounds are versatile building blocks for the synthesis of other types of nitrogen-containing compounds with potential biological properties. This review summarizes recent data regarding the preparation and properties of 4-membered nitrogen-containing heterocyclic rings, as well as their biological activities.

引用

页码：685 / 697

页数：13

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