The Zebrafish as Model for Deciphering the Regulatory Architecture of Vertebrate Genomes

被引：1
|
作者：
Rastegar, S. [1 ]
Straehle, U. [1 ,2 ]
机构：
[1] Karlsruhe Inst Technol, Inst Toxicol & Genet, Eggenstein Leopoldshafen, Germany
[2] Heidelberg Univ, Heidelberg, Germany
来源：
GENETICS, GENOMICS AND PHENOMICS OF FISH | 2016年 / 95卷
基金：
欧盟地平线“2020”;
关键词：
TRANSCRIPTION-FACTOR-BINDING; KEY DEVELOPMENTAL GENES; ENHANCER ACTIVITY MAPS; CIS-ACTING REGULATOR; SONIC-HEDGEHOG; WIDE ANALYSIS; FLOOR PLATE; CHIP-SEQ; ULTRACONSERVED ELEMENTS; INSERTIONAL MUTAGENESIS;
D O I：
10.1016/bs.adgen.2016.04.003
中图分类号：
S9 [水产、渔业];
学科分类号：
0908 ;
摘要：
Despite enormous progress to map cis-regulatory modules (CRMs), like enhancers and promoters in genomes, elucidation of the regulatory landscape of the developing embryo remains a challenge. The zebrafish embryo with its experimental virtues has a great potential to contribute to this endeavor. However, so far progress remained behind expectation. We discuss here available methods and their limitations and how the zebrafish embryo could contribute in the future to unravel the wiring of the vertebrate genome.
引用
收藏
页码：195 / 216
页数：22
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