The Zebrafish as Model for Deciphering the Regulatory Architecture of Vertebrate Genomes

被引：1
|
作者：
Rastegar, S. [1 ]
Straehle, U. [1 ,2 ]
机构：
[1] Karlsruhe Inst Technol, Inst Toxicol & Genet, Eggenstein Leopoldshafen, Germany
[2] Heidelberg Univ, Heidelberg, Germany
来源：
GENETICS, GENOMICS AND PHENOMICS OF FISH | 2016年 / 95卷
基金：
欧盟地平线“2020”;
关键词：
TRANSCRIPTION-FACTOR-BINDING; KEY DEVELOPMENTAL GENES; ENHANCER ACTIVITY MAPS; CIS-ACTING REGULATOR; SONIC-HEDGEHOG; WIDE ANALYSIS; FLOOR PLATE; CHIP-SEQ; ULTRACONSERVED ELEMENTS; INSERTIONAL MUTAGENESIS;
D O I：
10.1016/bs.adgen.2016.04.003
中图分类号：
S9 [水产、渔业];
学科分类号：
0908 ;
摘要：
Despite enormous progress to map cis-regulatory modules (CRMs), like enhancers and promoters in genomes, elucidation of the regulatory landscape of the developing embryo remains a challenge. The zebrafish embryo with its experimental virtues has a great potential to contribute to this endeavor. However, so far progress remained behind expectation. We discuss here available methods and their limitations and how the zebrafish embryo could contribute in the future to unravel the wiring of the vertebrate genome.
引用
收藏
页码：195 / 216
页数：22
相关论文
共 50 条
  • [31] Zebrafish epiboly as a model of vertebrate embryonic cell rearrangement
    Bruce, Ashley
    Winklbauer, Rudolf
    MECHANISMS OF DEVELOPMENT, 2009, 126 : S68 - S68
  • [32] New families of human regulatory RNA structures identified by comparative analysis of vertebrate genomes
    Parker, Brian J.
    Moltke, Ida
    Roth, Adam
    Washietl, Stefan
    Wen, Jiayu
    Kellis, Manolis
    Breaker, Ronald
    Pedersen, Jakob Skou
    GENOME RESEARCH, 2011, 21 (11) : 1929 - 1943
  • [33] Synorth: exploring the evolution of synteny and long-range regulatory interactions in vertebrate genomes
    Xianjun Dong
    David Fredman
    Boris Lenhard
    Genome Biology, 10
  • [34] Synorth: exploring the evolution of synteny and long-range regulatory interactions in vertebrate genomes
    Dong, Xianjun
    Fredman, David
    Lenhard, Boris
    GENOME BIOLOGY, 2009, 10 (08): : R86
  • [35] Deciphering metabolomics and lipidomics landscape in zebrafish hypertrophic cardiomyopathy model
    Jacob, Shana
    Abuarja, Tala
    Shaath, Rulan
    Hasan, Waseem
    Balayya, Saroja
    Abdelrahman, Doua
    Almana, Khalid
    Afreen, Hajira
    Hani, Ahmad
    Nomikos, Michail
    Fakhro, Khalid
    Elrayess, Mohamed A.
    Da'as, Sahar Isa
    SCIENTIFIC REPORTS, 2024, 14 (01):
  • [36] The zebrafish as a vertebrate model of functional aging and very gradual senescence
    Kishi, S
    Uchiyama, J
    Baughman, AM
    Goto, T
    Lin, MC
    Tsai, SB
    EXPERIMENTAL GERONTOLOGY, 2003, 38 (07) : 777 - 786
  • [37] Interaction of mercury and selenium in the larval stage zebrafish vertebrate model
    MacDonald, Tracy C.
    Korbas, Malgorzata
    James, Ashley K.
    Sylvain, Nicole J.
    Hackett, Mark J.
    Nehzati, Susan
    Krone, Patrick H.
    George, Graham N.
    Pickering, Ingrid J.
    METALLOMICS, 2015, 7 (08) : 1247 - 1255
  • [38] Zebrafish: A model vertebrate suitable for the analysis of human genetic disorders
    Ota, Satoshi
    Kawahara, Atsuo
    CONGENITAL ANOMALIES, 2014, 54 (01) : 8 - 11
  • [39] Zebrafish: A Premier Vertebrate Model for Biomedical Research in Indian Scenario
    Sarasamma, Sreeja
    Varikkodan, Muhammed Muhsin
    Liang, Sung-Tzu
    Lin, Yen-Chang
    Wang, Wen-Pin
    Hsiao, Chung-Der
    ZEBRAFISH, 2017, 14 (06) : 589 - 605
  • [40] Developmental biology - Zebrafish embryology builds better model vertebrate
    Roush, W
    SCIENCE, 1996, 272 (5265) : 1103 - 1103
12345