The zebrafish has unique advantages for understanding the evolution of vertebrate immunity and to model human diseases. In this review, we will firstly give an overview of the current knowledge on vertebrate innate immune receptors with special emphasis on the inflammasome and then summarize the main contribution of the zebrafish model to this field, including to the identification of novel inflammasome components and to the mechanisms involved in its activation, assembly and clearance of intracellular bacteria.
机构:
Walter & Eliza Hall Inst Med Res, Canc & Haematol Div, Parkville, Vic 3052, Australia
Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, AustraliaWalter & Eliza Hall Inst Med Res, Canc & Haematol Div, Parkville, Vic 3052, Australia
Ellett, Felix
Lieschke, Graham J.
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Walter & Eliza Hall Inst Med Res, Canc & Haematol Div, Parkville, Vic 3052, AustraliaWalter & Eliza Hall Inst Med Res, Canc & Haematol Div, Parkville, Vic 3052, Australia
机构:
Wayne State Univ, Sch Med, Dept Immunol & Microbiol, Detroit, MI 48201 USAWayne State Univ, Sch Med, Dept Immunol & Microbiol, Detroit, MI 48201 USA
Phelps, Hilary A.
Neely, Melody N.
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Wayne State Univ, Sch Med, Dept Immunol & Microbiol, Detroit, MI 48201 USAWayne State Univ, Sch Med, Dept Immunol & Microbiol, Detroit, MI 48201 USA