The zebrafish: A research model to understand the evolution of vertebrate immunity

被引：26
|
作者：
Garcia-Moreno, Diana [1 ,2 ]
Tyrkalska, Sylwia D. [1 ,2 ]
Valera-Perez, Ana [1 ,2 ]
Gomez-Abenza, Elena [1 ,2 ]
Perez-Oliva, Ana B. [1 ,2 ]
Mulero, Victoriano [1 ,2 ]
机构：
[1] Univ Murcia, Fac Biol, Dept Biol Celular & Histol, Murcia, Spain
[2] Inst Murciano Invest Biosanitaria IMTB Arrixaca, Murcia, Spain
来源：
FISH & SHELLFISH IMMUNOLOGY | 2019年 / 90卷
关键词：
NF-KAPPA-B; NONCANONICAL INFLAMMASOME ACTIVATION; NOD-LIKE RECEPTORS; HOST-CELL DEATH; IN-VIVO; MOLECULAR-CLONING; FAMILY-MEMBER; IL-1; FAMILY; GASDERMIN D; PATHOGEN RECOGNITION;
D O I：
10.1016/j.fsi.2019.04.067
中图分类号：
S9 [水产、渔业];
学科分类号：
0908 ;
摘要：
The zebrafish has unique advantages for understanding the evolution of vertebrate immunity and to model human diseases. In this review, we will firstly give an overview of the current knowledge on vertebrate innate immune receptors with special emphasis on the inflammasome and then summarize the main contribution of the zebrafish model to this field, including to the identification of novel inflammasome components and to the mechanisms involved in its activation, assembly and clearance of intracellular bacteria.
引用
收藏
页码：215 / 222
页数：8
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