Antioxidant Properties of the Manzamenones from the Tropical Marine Sponge Plakortis sp.

被引：2
|
作者：
Cho, MyoungLae [1 ,2 ]
Lee, Yeon-Ju [1 ]
Lee, Jong Seok [1 ]
Shin, Hee-Jae [1 ]
Lee, Hyi-Seung [1 ]
机构：
[1] Korea Inst Ocean Sci & Technol, Marine Nat Prod Chem Lab, Busan, South Korea
[2] Natl Dev Inst Korean Med Gyeongsan, Gyongsan, South Korea
来源：
NATURAL PRODUCT COMMUNICATIONS | 2020年 / 15卷 / 01期
关键词：
manzamenone; sponge; structural property; Plakortis; antioxidant; FATTY-ACID DERIVATIVES; ANALOGS;
D O I：
10.1177/1934578X19896694
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new manzamenone derivative (4) and four known manzamenones were isolated from the tropical marine sponge Plakortis sp. These compounds exhibited an improved inhibitory effect against the copper-induced low-density lipoprotein oxidation. To identify their structural properties for antioxidant effects, 43-O-methylmanzamenone A (2) has been exposed oxidative conditions such as hydrogen peroxide, mCPBA and primary alkyl amines to give various derivatives (6)-(9). The structures of the compounds were determined by spectroscopic analyses and comparison with literature values.
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页数：6
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