Manzamenones L-N, new dimeric fatty-acid derivatives from an Okinawan marine sponge Plakortis sp.

被引：9
|
作者：
Kubota, Takaaki [1 ]
Ishiguro, Yuichiro [1 ]
Takahashi-Nakaguchi, Azusa [2 ]
Fromont, Jane [3 ]
Gonoi, Tohru [2 ]
Kobayashi, Jun'ichi [1 ]
机构：
[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan
[2] Chiba Univ, Mycol Res Ctr, Chiba 2600856, Japan
[3] Western Australian Museum, Welshpool Dc, WA 6986, Australia
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 01期
关键词：
Marine sponge; Plakortis sp; Manzamenones L-N; Dimeric fatty-acid derivative; Antimicrobial activity; CHEMICAL PREDISPOSITION; NATURAL-PRODUCTS; DNA-POLYMERASES; PLAKORIDINE-A; PLAKEVULIN-A; UNTENONE-A;
D O I：
10.1016/j.bmcl.2012.10.109
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Three new polyketides, manzamenones L-N (1-3), have been isolated from an Okinawan marine sponge of the genus Plakortis. The structures of 1-3 were elucidated on the basis of spectroscopic data. Manzamenones L-N (1-3) were new dimeric fatty-acid derivatives consisting of a tetrahydroindenone with three carboxy groups and two hexadecanyl chains. Manzamenones M (2) and N (3) showed antimicrobial activity against several bacteria and fungi. (c) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：244 / 247
页数：4
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