Synthesis of a new class of HIV-1 inhibitors

被引：0

作者：

Farese-Di Giorgio, A

Pairot, S

Patino, N

Condom, R ^{[1
]}

Di Giorgio, C

Aumelas, A

Aubertin, AM

Guedj, R

机构：

[1] Univ Nice, Chim Bioorgan Lab, CNRS ESA 6001, F-06108 Nice 2, France

[2] Fac Pharm Montpellier, CNRS UMR C9955, Ctr Biochim Struct, F-34060 Montpellier, France

[3] Inst Virol, INSERM U74, F-67000 Strasbourg, France

来源：

NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 02期

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new family of molecules potentially inhibitors of the HIV-1 Tat-TAR complex was prepared. These compounds are constituted by dinucleotide analogs (PNA dimer) bound, through a linker, to an arginine residue. In this series, several molecules inhibit viral development in cell culture with a micromolar IC50 and without cellular toxicity until 200 mu M concentration.

引用

页码：263 / 275

页数：13

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