Synthesis of a new class of HIV-1 inhibitors

被引：0

作者：

Farese-Di Giorgio, A

Pairot, S

Patino, N

Condom, R ^{[1
]}

Di Giorgio, C

Aumelas, A

Aubertin, AM

Guedj, R

机构：

[1] Univ Nice, Chim Bioorgan Lab, CNRS ESA 6001, F-06108 Nice 2, France

[2] Fac Pharm Montpellier, CNRS UMR C9955, Ctr Biochim Struct, F-34060 Montpellier, France

[3] Inst Virol, INSERM U74, F-67000 Strasbourg, France

来源：

NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 02期

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new family of molecules potentially inhibitors of the HIV-1 Tat-TAR complex was prepared. These compounds are constituted by dinucleotide analogs (PNA dimer) bound, through a linker, to an arginine residue. In this series, several molecules inhibit viral development in cell culture with a micromolar IC50 and without cellular toxicity until 200 mu M concentration.

引用

页码：263 / 275

页数：13

共 50 条

[31] Synthesis of triazenopyrazole derivatives as potential inhibitors of HIV-1
Larsen, JS
Zahran, MA
Pedersen, EB
Nielsen, C
MONATSHEFTE FUR CHEMIE, 1999, 130 (09): : 1167 - 1173
[32] Synthesis of potential inhibitors of HIV-1 protease dimerization
Pinyol, Eulalia
Cruz, Montse
Rubiralta, Mario
Giralt, Ernest
Diez, Anna
Peptides 2004, Proceedings: BRIDGES BETWEEN DISCIPLINES, 2005, : 619 - 620
[33] Synthesis of styrylquinoline carboxamides for HIV-1 integrase inhibitors
Lee, Seung Uk
Park, Jang Hyun
Lee, Jae Yeol
Shin, Cha-Gyun
Chung, Bong Young
Lee, Yong Sup
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2006, 27 (11) : 1888 - 1890
[34] Synthesis and primary evaluation of novel HIV-1 inhibitors
El Safadi, Yazan
Marquet, Roland
Aubertin, Anne-Marie
Vivet-Boudou, Valerie
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2007, 26 (8-9): : 1161 - 1165
[35] A NEW HYDROXYETHYLAMINE CLASS OF HIV-1 PROTEASE INHIBITORS WITH HIGH ANTIVIRAL POTENCY AND ORAL BIOAVAILABILITY
KIM, BM
VACCA, JP
GUARE, JP
HANIFIN, CM
DARKE, PL
ZUGAY, JA
EMINI, EA
SCHLEIF, W
LIN, JH
CHEN, IW
OSTOVIC, D
HUFF, JR
ANDERSON, PS
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1994, 208 : 3 - MEDI
[36] A new class of capsid-targeting inhibitors that specifically block HIV-1 nuclear import
Boulay, Aude
Quevarec, Emmanuel
Malet, Isabelle
Nicastro, Giuseppe
Chamontin, Celia
Perrin, Suzon
Henriquet, Corinne
Pugniere, Martine
Courgnaud, Valerie
Blaise, Mickael
Marcelin, Anne-Genevieve
Taylor, Ian A.
Chaloin, Laurent
Arhel, Nathalie J.
EMBO MOLECULAR MEDICINE, 2024, 16 (11) : 2918 - 2945
[37] KuINins as a New Class of HIV-1 Inhibitors That Block Post-Integration DNA Repair
Anisenko, Andrey
Galkin, Simon
Mikhaylov, Andrey A.
Khrenova, Maria G.
Agapkina, Yulia
Korolev, Sergey
Garkul, Lidia
Shirokova, Vasilissa
Ikonnikova, Viktoria A.
Korlyukov, Alexander
Dorovatovskii, Pavel
Baranov, Mikhail
Gottikh, Marina
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (24)
[38] Truncated Reverse Isoxazolidinyl Nucleosides: A New Class of Allosteric HIV-1 Reverse Transcriptase Inhibitors
Romeo, Roberto
Giofre, Salvatore V.
Macchi, Beatrice
Balestrieri, Emanuela
Mastino, Antonio
Merino, Pedro
Carnovale, Caterina
Romeo, Giovanni
Chiacchio, Ugo
CHEMMEDCHEM, 2012, 7 (04) : 565 - 569
[39] Natural variation of HIV-1 group M integrase: Implications for a new class of antiretroviral inhibitors
Soo-Yon Rhee
Tommy F Liu
Mark Kiuchi
Rafael Zioni
Robert J Gifford
Susan P Holmes
Robert W Shafer
Retrovirology, 5
[40] Natural variation of HIV-1 group M integrase: Implications for a new class of antiretroviral inhibitors
Rhee, Soo-Yon
Liu, Tommy F.
Kiuchi, Mark
Zioni, Rafael
Gifford, Robert J.
Holmes, Susan P.
Shafer, Robert W.
RETROVIROLOGY, 2008, 5 (1)

← 1 2 3 4 5 →