Concise and efficient synthesis of 4-fluoro-1H-pyrrolo[2,3-b]pyridine

被引：42

作者：

Thibault, C ^{[1
]}

L'Heureux, A ^{[1
]}

Bhide, RS ^{[1
]}

Ruel, R ^{[1
]}

机构：

[1] Bristol Myers Squibb Co, Dept Discovery Chem, Pharmaceut Res Inst, Quebec City, PQ J5R 1J1, Canada

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 26期

关键词：

D O I：

10.1021/ol036030z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Two routes describing the preparation of 4-fluoro-1H-pyrrolo[2,3-b]pyridine (4a) from 1H-pyrrolo[2,3-b]pyridine N-oxide (1) are presented, Regioselective fluorination was achieved using either the Balz-Schiemann reaction or lithium-halogen exchange.

引用

页码：5023 / 5025

页数：3

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