Concise and efficient synthesis of 4-fluoro-1H-pyrrolo[2,3-b]pyridine

被引：42
|
作者：
Thibault, C [1 ]
L'Heureux, A [1 ]
Bhide, RS [1 ]
Ruel, R [1 ]
机构：
[1] Bristol Myers Squibb Co, Dept Discovery Chem, Pharmaceut Res Inst, Quebec City, PQ J5R 1J1, Canada
来源：
ORGANIC LETTERS | 2003年 / 5卷 / 26期
关键词：
D O I：
10.1021/ol036030z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] Two routes describing the preparation of 4-fluoro-1H-pyrrolo[2,3-b]pyridine (4a) from 1H-pyrrolo[2,3-b]pyridine N-oxide (1) are presented, Regioselective fluorination was achieved using either the Balz-Schiemann reaction or lithium-halogen exchange.
引用
收藏
页码：5023 / 5025
页数：3
相关论文
共 50 条
  • [41] SYNTHESIS OF FURO[2,3-b]PYRIDINE
    Chang, Meng-Yang
    Tai, Hang-Yi
    HETEROCYCLES, 2011, 83 (10) : 2373 - 2380
  • [42] SYNTHESIS OF FURO[2,3-B]PYRIDINE
    MCFARLAND, JW
    WOLLERMAN, RP
    SADLER, WC
    COLEMAN, GN
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1971, 8 (05) : 735 - +
  • [43] SYNTHESIS OF SELENOLO[2,3-B]PYRIDINE
    PIRSON, P
    CHRISTIA.L
    BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE, 1973, (02): : 704 - 707
  • [44] SYNTHESIS OF PYRROLO[2,3-B]PYRROLE DERIVATIVES
    BLANTON, CD
    WIDBY, JF
    BRIGGS, FH
    JOURNAL OF ORGANIC CHEMISTRY, 1971, 36 (25): : 3929 - &
  • [45] Synthesis, characterization, crystal structure, and DFT study of 3,4-Diphenyl-1H-pyrrolo[2,3-b]pyridine
    Yang, Ni
    Song, Wenfei
    Liu, Xiangxiang
    Ban, Shifeng
    Liao, Tianhui
    Wang, Yuan
    Zhou, Zhixu
    MOLECULAR CRYSTALS AND LIQUID CRYSTALS, 2023, 765 (01) : 26 - 36
  • [46] SYNTHESIS OF PYRIDINE-2(1H)-THIONE AND THIENO[2,3-B]-PYRIDINE DERIVATIVES
    ELGEMEIE, GEH
    ALNAIMI, IS
    ALARAB, HF
    HETEROCYCLES, 1992, 34 (09) : 1721 - 1728
  • [47] Synthesis and Evaluation of 1H-Pyrrolo[2,3-b]pyridine Derivatives as Novel Immunomodulators Targeting Janus Kinase 3
    Nakajima, Yutaka
    Tojo, Takashi
    Morita, Masataka
    Hatanaka, Keiko
    Shirakami, Shohei
    Tanaka, Akira
    Sasaki, Hiroshi
    Nakai, Kazuo
    Mukoyoshi, Koichiro
    Hamaguchi, Hisao
    Takahashi, Fumie
    Moritomo, Ayako
    Higashi, Yasuyuki
    Inoue, Takayuki
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2015, 63 (05) : 341 - 353
  • [48] SYNTHESIS OF 5H-CYCLOHEPTA[4,5]PYRROLO[2,3-B]INDOLES
    YAMANE, K
    YAMAMOTO, H
    SATOH, A
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1986, 59 (10) : 3326 - 3328
  • [49] SYNTHESIS OF PYRROLO[2,3-B]AZEPIN-4-ONE DERIVATIVES
    VORA, MM
    YI, CS
    BLANTON, CD
    HETEROCYCLES, 1981, 16 (03) : 399 - 403
  • [50] SYNTHESIS OF PYRROLO[2,3-B]PYRAZINE (4,7-DIAZAINDOLE)
    AZIMOV, VA
    YAKHONTO.LN
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1973, (06): : 858 - 858
12345