NOVEL PYRROLO[2,3-b]PYRIDINE AND PYRROLO[2,3-d] PYRIMIDINE DERIVATIVES: DESIGN, SYNTHESIS, AND STRUCTURE ELUCIDATION

被引：0

作者：

Hilmy, Khaled M. H. ^{[1
]}

Kishk, Fawzya N. M. ^{[1
]}

Shahen, Esmat B. A. ^{[2
]}

Hawata, Mohamed A. ^{[1
]}

机构：

[1] Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32511, Egypt

[2] Al Azhar Univ Girls, Fac Med, Dept Biochem Dept, Cairo 11765, Egypt

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA | 2023年 / 37卷 / 04期

关键词：

1H-Pyrrolo[2; 3-b]pyridine; 3-d]pyrimidines; Active methylene compounds; BIOLOGICAL EVALUATION;

D O I：

10.4314/bcse.v37i4.14

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A cyclo condensation reaction is an effective method for a two-component reaction of 2-amino-1,5-diphenyl-1H-pyrrole-3-carbonitrile 3a-c and active methylene compounds in acetic acid and catalytic hydrochloric acid to produce new substituted 1H-pyrrolo[2,3-b]pyridine 4a-c, 5a-c, and 6a-c have been established. Additionally, a new series of substituted 1H-pyrrolo[2,3-d]pyrimidines 7a-c and 8a-c could be synthesized utilizing a feasible and efficient approach, including urea and thiourea substrates. Spectroscopic data IR, MS, 1H, and 13C NMR, as well as elemental analyses, elucidated these compounds' structures.

引用

页码：983 / 992

页数：10

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