Stochastic Simulations in the dynamical model of p53-Mdm2 feedback loop regulated by p14/19ARF

被引：0
|
作者：
Liu, Hui [1 ]
Han, Yingrong [1 ]
Zhan, Yong [1 ]
Zhang, Yuhong [1 ]
Yuan, Changqing [1 ]
Liu, Yuzhi [1 ]
Zhao, Tongjun [1 ]
Zhuo, Yizhong [2 ]
机构：
[1] Hebei Univ Technol, Inst Biophys, Sch Sci, Tianjin 300130, Peoples R China
[2] China Inst Atom Energy, Beijing 102413, Peoples R China
来源：
JOURNAL OF COMPUTATIONAL AND THEORETICAL NANOSCIENCE | 2007年 / 4卷 / 7-8期
关键词：
stochastic; dynamics; p53; mdm2; p14/19ARF;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We propose a stochastic dynamical model to study the dynamical mechanism of the negative feedback loop composed of p53 and Mdm2 proteins that are regulated by p14/19ARF The different stochastic oscillatory behaviors of p53 and Mdm2 proteins that are regulated by p14/19ARF in individual cells are described in our stochastic dynamical model. The results help us build a basal network to reflect the stochastic oscillatory behaviors between p53, Mdm2 and p14/19ARF The stochastic dynamical model of p53-Mdm2 feedback loop that is regulated by p14/19ARF and its numerical results will help us understand the stochastic oscillatory behavior of p53, Mdm2 and p14/19ARF more deeply and rationally. It will also help us study the stochastic relations among the network of different proteins, and study how the stochastic factor influences the feedback loop.
引用
收藏
页码：1305 / 1310
页数：6
相关论文
共 50 条
  • [1] A Dynamical model on the network of p53-Mdm2 feedback loop regulated by p14/19ARF
    Liu, Hui
    Han, Ying-Rong
    Zhan, Yong
    Chen, Ya-Fei
    Zhang, Yu-Hong
    Yu, Hui
    Zhao, Tong-Jun
    Zhuo, Yi-Zhong
    2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16, 2007, : 4235 - +
  • [2] Dynamical Model of P53-Mdm2-P14/19ARF Network to Radiation in Population of Cells
    Liu, Hui
    Han, Yingrong
    Chen, Yafei
    Zhang, Suhua
    Zhao, Tongjun
    Zhan, Yong
    2009 FOURTH INTERNATIONAL CONFERENCE ON BIO-INSPIRED COMPUTING: THEORIES AND APPLICATIONS, PROCEEDINGS, 2009, : 254 - 256
  • [3] Cooperative Mechanism of P14/19ARF and Noise in P53 Network
    Liu, Hui
    Zhang, Suhua
    Hang, Yingrong
    Pang, Chunli
    JOURNAL OF COMPUTATIONAL AND THEORETICAL NANOSCIENCE, 2014, 11 (08) : 1833 - 1837
  • [4] Oscillations by the p53-Mdm2 feedback loop
    Lahav, Galit
    CELLULAR OSCILLATORY MECHANISMS, 2008, 641 : 28 - 38
  • [5] Pinning Control for the p53-Mdm2 Network Dynamics Regulated by p14ARF
    Suarez, Oscar J.
    Vega, Carlos J.
    Sanchez, Edgar N.
    Gonzalez-Santiago, Ana E.
    Rodriguez-Jorge, Otoniel
    Alanis, Alma Y.
    Chen, Guanrong
    Hernandez-Vargas, Esteban A.
    FRONTIERS IN PHYSIOLOGY, 2020, 11
  • [6] A Simplified Dynamic Model for the p53-Mdm2 Feedback Loop
    Shi, Xiao-Min
    Qin, Kai-Rong
    Liu, Zeng-Rong
    Zheng, Yu-Fan
    2013 10TH IEEE INTERNATIONAL CONFERENCE ON CONTROL AND AUTOMATION (ICCA), 2013, : 264 - 267
  • [7] Dynamical analysis of a delayed p53 oscillator model with p53-Mdm2 feedback
    Yang, Hongli
    Huo, Ruimin
    Liu, Nan
    Yang, Liangui
    RESULTS IN PHYSICS, 2022, 40
  • [8] Dynamical analysis of a delayed p53 oscillator model with p53-Mdm2 positive feedback
    Yang, Hongli
    Huo, Ruimin
    Liu, Nan
    Yang, Liangui
    RESULTS IN PHYSICS, 2022, 40
  • [9] Stochastic Modeling and Simulation of the p53-MDM2/MDMX Loop
    Cai, Xiaodong
    Yuan, Zhi-Min
    JOURNAL OF COMPUTATIONAL BIOLOGY, 2009, 16 (07) : 917 - 933
  • [10] Dynamics of the p53-Mdm2 feedback loop in individual cells
    Lahav, G
    Rosenfeld, N
    Sigal, A
    Geva-Zatorsky, N
    Levine, AJ
    Elowitz, MB
    Alon, U
    NATURE GENETICS, 2004, 36 (02) : 147 - 150
12345