Dynamical Model of P53-Mdm2-P14/19ARF Network to Radiation in Population of Cells

被引：0
|
作者：
Liu, Hui [1 ]
Han, Yingrong [1 ]
Chen, Yafei [1 ]
Zhang, Suhua [1 ]
Zhao, Tongjun [1 ]
Zhan, Yong [1 ]
机构：
[1] Hebei Univ Technol, Inst Biophys, Tianjin 300130, Peoples R China
来源：
2009 FOURTH INTERNATIONAL CONFERENCE ON BIO-INSPIRED COMPUTING: THEORIES AND APPLICATIONS, PROCEEDINGS | 2009年
关键词：
p53; Mdm2; P14/19ARF; Dynamical Model; P53-MDM2 FEEDBACK LOOP; DNA-DAMAGE; P53; MDM2; EXPRESSION;
D O I：
暂无
中图分类号：
TP18 [人工智能理论];
学科分类号：
081104 ; 0812 ; 0835 ; 1405 ;
摘要：
From the recent experiments of gamma radiation and models given before, we study the dynamical model of p53 and Mdm2 regulated by p14/19ARF in population of cells. In order to study how they infect the mechanism of the negative feedback loop, we give numerical results to study the oscillatory features of p53, Mdm2 and p14/19ARF in population of cells. The dynamical model and results will help us understand the oscillatory features of p53, Mdm2 and p14/19ARF to radiation in population of cells.
引用
收藏
页码：254 / 256
页数：3
相关论文
共 50 条
  • [1] A Dynamical model on the network of p53-Mdm2 feedback loop regulated by p14/19ARF
    Liu, Hui
    Han, Ying-Rong
    Zhan, Yong
    Chen, Ya-Fei
    Zhang, Yu-Hong
    Yu, Hui
    Zhao, Tong-Jun
    Zhuo, Yi-Zhong
    2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16, 2007, : 4235 - +
  • [2] Stochastic Simulations in the dynamical model of p53-Mdm2 feedback loop regulated by p14/19ARF
    Liu, Hui
    Han, Yingrong
    Zhan, Yong
    Zhang, Yuhong
    Yuan, Changqing
    Liu, Yuzhi
    Zhao, Tongjun
    Zhuo, Yizhong
    JOURNAL OF COMPUTATIONAL AND THEORETICAL NANOSCIENCE, 2007, 4 (7-8) : 1305 - 1310
  • [3] Cooperative Mechanism of P14/19ARF and Noise in P53 Network
    Liu, Hui
    Zhang, Suhua
    Hang, Yingrong
    Pang, Chunli
    JOURNAL OF COMPUTATIONAL AND THEORETICAL NANOSCIENCE, 2014, 11 (08) : 1833 - 1837
  • [4] MYCN interaction with the p53/MDM2/p14ARF network in neuroblastoma and response to p53-MDM2 antagonists
    Gamble, Laura
    Tweddle, Deborah
    Lunec, John
    CANCER RESEARCH, 2009, 69
  • [5] Pinning Control for the p53-Mdm2 Network Dynamics Regulated by p14ARF
    Suarez, Oscar J.
    Vega, Carlos J.
    Sanchez, Edgar N.
    Gonzalez-Santiago, Ana E.
    Rodriguez-Jorge, Otoniel
    Alanis, Alma Y.
    Chen, Guanrong
    Hernandez-Vargas, Esteban A.
    FRONTIERS IN PHYSIOLOGY, 2020, 11
  • [6] p14ARF-MDM2-p53 immunohistochemical surveillance in retinoblastoma
    Carvalho, L.
    Alarcao, A.
    Fonseca, C.
    Teixeira, L.
    Aguiar, M. J.
    Proenca, R.
    VIRCHOWS ARCHIV, 2010, 457 (02) : 231 - 231
  • [7] p53 activation in chronic radiation-treated breast cancer cells: Regulation of MDM2/p14ARF
    Xia, LQ
    Paik, A
    Li, JJ
    CANCER RESEARCH, 2004, 64 (01) : 221 - 228
  • [8] Regulation of the p14ARF-Mdm2-p53 pathway: An overview in breast cancer
    Agrawal, Anshu
    Yang, Jianhui
    Murphy, Richard F.
    Agrawal, Devendra K.
    EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2006, 81 (02) : 115 - 122
  • [9] Retinoblastoma and protein expression of P14ARF, MDM2 and P53
    Carvalho, L. M.
    Alarcao, A. M.
    Teixeira, C. L.
    Fonseca, M. C.
    Proenca, R. D.
    HISTOPATHOLOGY, 2010, 57 : 210 - 210
  • [10] Cooperativity of p19ARF, Mdm2, and p53 in murine tumorigenesis
    Lynette Moore
    Sundaresan Venkatachalam
    Hannes Vogel
    Julie C Watt
    Chao-Ling Wu
    Heather Steinman
    Stephen N Jones
    Lawrence A Donehower
    Oncogene, 2003, 22 : 7831 - 7837
12345