Stochastic Simulations in the dynamical model of p53-Mdm2 feedback loop regulated by p14/19ARF

被引：0

作者：

Liu, Hui ^{[1
]}

Han, Yingrong ^{[1
]}

Zhan, Yong ^{[1
]}

Zhang, Yuhong ^{[1
]}

Yuan, Changqing ^{[1
]}

Liu, Yuzhi ^{[1
]}

Zhao, Tongjun ^{[1
]}

Zhuo, Yizhong ^{[2
]}

机构：

[1] Hebei Univ Technol, Inst Biophys, Sch Sci, Tianjin 300130, Peoples R China

[2] China Inst Atom Energy, Beijing 102413, Peoples R China

来源：

JOURNAL OF COMPUTATIONAL AND THEORETICAL NANOSCIENCE | 2007年 / 4卷 / 7-8期

关键词：

stochastic; dynamics; p53; mdm2; p14/19ARF;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We propose a stochastic dynamical model to study the dynamical mechanism of the negative feedback loop composed of p53 and Mdm2 proteins that are regulated by p14/19ARF The different stochastic oscillatory behaviors of p53 and Mdm2 proteins that are regulated by p14/19ARF in individual cells are described in our stochastic dynamical model. The results help us build a basal network to reflect the stochastic oscillatory behaviors between p53, Mdm2 and p14/19ARF The stochastic dynamical model of p53-Mdm2 feedback loop that is regulated by p14/19ARF and its numerical results will help us understand the stochastic oscillatory behavior of p53, Mdm2 and p14/19ARF more deeply and rationally. It will also help us study the stochastic relations among the network of different proteins, and study how the stochastic factor influences the feedback loop.

引用

页码：1305 / 1310

页数：6

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