Predisposition to prolonged neutropenia after chemotherapy for paediatric acute myeloid leukaemia is associated with better prognosis in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study

被引：4

作者：

Aoki, Takahiro ^{[1
]}

Takahashi, Hiroyuki ^{[2
]}

Tanaka, Shiro ^{[3
]}

Shiba, Norio ^{[4
]}

Hasegawa, Daiichiro ^{[5
]}

Iwamoto, Shotaro ^{[6
]}

Terui, Kiminori ^{[7
]}

Moritake, Hiroshi ^{[8
]}

Nakayama, Hideki ^{[9
]}

Shimada, Akira ^{[10
]}

Koh, Katsuyoshi ^{[11
]}

Goto, Hiroaki ^{[12
]}

Kosaka, Yoshiyuki ^{[5
]}

Saito, Akiko M. ^{[13
]}

Horibe, Keizo ^{[13
]}

Kinoshita, Akitoshi ^{[14
]}

Tawa, Akio ^{[15
]}

Taga, Takashi ^{[16
]}

Adachi, Souichi ^{[17
]}

Tomizawa, Daisuke ^{[18
]}

机构：

[1] Chiba Univ, Grad Sch Med, Dept Pediat, Chiba, Japan

[2] Toho Univ, Dept Pediat, Tokyo, Japan

[3] Kyoto Univ, Grad Sch Med, Dept Clin Biostat, Clin Biostat Course, Kyoto, Japan

[4] Yokohama City Univ Med, Grad Sch Med, Dept Pediat, Yokohama, Kanagawa, Japan

[5] Hyogo Prefectural Kobe Childrens Hosp, Dept Hematol Oncol, Kobe, Hyogo, Japan

[6] Mie Univ, Dept Pediat, Tsu, Mie, Japan

[7] Hirosaki Univ, Dept Pediat, Hirosaki, Aomori, Japan

[8] Univ Miyazaki, Fac Med, Div Pediat, Miyazaki, Japan

[9] Natl Hosp Org, Dept Pediat, Kyushu Canc Ctr, Fukuoka, Japan

[10] Okayama Univ Hosp, Dept Pediat Hematol Oncol, Okayama, Japan

[11] Saitama Childrens Med Ctr, Dept Hematol Oncol, Saitama, Japan

[12] Kanagawa Childrens Med Ctr, Div Hematol Oncol, Yokohama, Kanagawa, Japan

[13] Natl Hosp Org, Clin Res Ctr, Nagoya Med Ctr, Nagoya, Aichi, Japan

[14] St Marianna Univ, Sch Med, Dept Pediat, Kawasaki, Kanagawa, Japan

[15] Higashiosaka Aramoto Heiwa Clin, Higashiosaka, Osaka, Japan

[16] Shiga Univ Med Sci, Dept Pediat, Otsu, Shiga, Japan

[17] Kyoto Univ, Dept Human Hlth Sci, Kyoto, Japan

[18] Natl Ctr Child Hlth & Dev, Childrens Canc Ctr, Div Leukemia & Lymphoma, Tokyo, Japan

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2021年 / 193卷 / 01期

关键词：

acute myeloid leukaemia; chemosensitivity; children; myelosuppression; neutropenia; LYMPHOBLASTIC-LEUKEMIA; CHILDREN; RELAPSE; THERAPY;

D O I：

10.1111/bjh.16656

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The variability in myelosuppression after chemotherapy for acute myeloid leukaemia (AML) can affect its prognosis; however, the underlying mechanism remains controversial. In the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study, we showed that prolonged neutropenia was associated with high overall survival (P = 0 center dot 011) and low frequency of relapse (P = 0 center dot 042) in patients without granulocyte-colony stimulating factor (G-CSF) who completed the indicated treatment protocol. Our data indicate that predisposition to prolonged neutropenia after chemotherapy is correlated with a better outcome of AML treatment. Our results promote the usage of individualised drug dosing strategies to improve the therapeutic outcome in AML patients.

引用

页码：176 / 180

页数：5

共 50 条

[31] Complex and monosomal karyotype are distinct cytogenetic entities with an adverse prognostic impact in paediatric acute myeloid leukaemia. A NOPHO-DBH-AML study
Bager, Ninna
Juul-Dam, Kristian L.
Sandahl, Julie D.
Abrahamsson, Jonas
Beverloo, Berna
de Bont, Eveline S. J. M.
Ha, Shau-Yin
Jahnukainen, Kirsi
Jonsson, Olafur G.
Kaspers, Gertjan L.
Kovalova, Zhanna
Lausen, Birgitte
De Moerloose, Barbara
Noren-Nystroem, Ulrika
Palle, Josefine
Saks, Kadri
Zeller, Bernward
Kjeldsen, Eigil
Hasle, Henrik
BRITISH JOURNAL OF HAEMATOLOGY, 2018, 183 (04) : 618 - 628
[32] A Retrospective Study of Pediatric Patients With Low- or Intermediate-Risk Acute Myeloid Leukemia Who Underwent Allogeneic Hematopoietic Cell Transplantation for the AML-05 Study Conducted by the Japanese Pediatric Leukemia/ Lymphoma Study Group
Hashii, Yoshiko
Kawaguchi, Koji
Kurakami, Hiroyuki
Umeda, Katsutsugu
Hasegawa, Daiichiro
Taki, Tomohiko
Hyakuna, Nobuyuki
Ishida, Hiroyuki
Takahashi, Yoshiyuki
Nagasawa, Masayuki
Yabe, Hiromasa
Yano, Michihiro
Nakazawa, Yozo
Fujisaki, Hiroyuki
Matsumoto, Kimikazu
Yanagimachi, Masakatsu
Yoshida, Nao
Kakuda, Harumi
Satou, Atsushi
Tabuchi, Ken
Tomizawa, Daisuke
Taga, Takashi
Adachi, Souichi
Koh, Katsuyoshi
Kato, Koji
TRANSPLANTATION AND CELLULAR THERAPY, 2024, 30 (11): : 1102e1 - 1102e12
[33] The outcomes of relapsed acute myeloid leukemia in children: Results from the Japanese Pediatric Leukemia/Lymphoma Study Group AML-05R study
Moritake, Hiroshi
Tanaka, Shiro
Miyamura, Takako
Nakayama, Hideki
Shiba, Norio
Shimada, Akira
Terui, Kiminori
Yuza, Yuki
Koh, Katsuyoshi
Goto, Hiroaki
Kakuda, Harumi
Saito, Akiko
Hasegawa, Daisuke
Iwamoto, Shotaro
Taga, Takashi
Adachi, Souichi
Tomizawa, Daisuke
PEDIATRIC BLOOD & CANCER, 2021, 68 (01)
[34] Results of immunosupressive therapy in children with severe aplastic anaemia. Report Polish paediatric leukaemia and lymphoma study group
Pawelec, K.
Matysiak, M.
Niewiadomska, E.
Stefaniak, J.
Kowalczyk, J.
Balwierz, E. Zalecka-Czepko' W.
Szmyd, K.
Chybicka, A.
Bubala, H. B.
Sonta-Jakimczyk, D.
Krauze, A.
Kurylak, A.
Wysocki, M.
Kaczmarczyk-Kanod, M.
Wachowiak, J.
Karolczyk, I.
Stolarska, M.
Pergud-Pogorzelski, J.
Urasinski, T.
Leszczynska, E.
Krawczuk-Rybak, M.
Wlazlowski, M. W.
Balcerska, A.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2007, 92 : 26 - 26
[35] PROGNOSTIC FACTORS IN T ACUTE LYMPHOBLASTIC LEUKAEMIA: COLLABORATIVE STUDY OF THE BIOLOGICAL COMMITTEE OF THE LEUKAEMIA GROUP OF THE SPANISH SOCIETY OF PAEDIATRIC HEMATO-ONCOLOGY (SEHOP)
Garcia Nerea, Vega
Burriel Montserrat, Torrebadell
Velasco Antonio, Jimenez
Blanco Margarita, Ortega
Acha Lorea, Abad
Canela Marta, Pratcorona
Marin Luz, Munoz
Roberta, Malatesta
Rubio Lourdes, Calvente
Temprano Albert, Catala
Moreno Ruben, Berrueco
Llobet Anna, Ruiz
Aguado Camino, Estella
del Castillo Maria, Trabazo
Saladrigues Anna, Alonso
Meda Montserrat, Mesegue
Martinez Antonia, Pascual
Atienza Alvaro, Lassaletta
Serra Isabel, Badell
Gatell Sandra, Pisa
Maria Rosario, Velasco Arribas
Jose Luis, Dapena Diaz
Sola Susana, Rives
Orellana Manuel, Ramirez
Guijosa Mireia, Camos
HAEMATOLOGICA, 2016, 101 : 162 - 163
[36] Immune function in children under chemotherapy for standard risk acute lymphoblastic leukaemia - a prospective study of 20 paediatric patients
Eyrich, Matthias
Wiegering, Verena
Lim, Annick
Schrauder, Andre
Winkler, Beate
Schlegel, Paul G.
BRITISH JOURNAL OF HAEMATOLOGY, 2009, 147 (03) : 360 - 370
[37] Prognosis of Pediatric Acute Myeloid Leukemia with KMT2A-MLLT3 According to DNA Methylation Patterns: Jccg JPLSG AML-05 Study
Yamato, Genki
Kawai, Tomoko
Shiba, Norio
Hara, Yusuke
Ohki, Kentaro
Kaburagi, Taeko
Ishikita, Etsuko
Kawasaki, Hirohide
Yoshida, Kenichi
Shiraishi, Yuichi
Miyano, Satoru
Kiyokawa, Nobutaka
Tomizawa, Daisuke
Shimada, Akira
Sotomatsu, Manabu
Takizawa, Takumi
Adachi, Souichi
Taga, Takashi
Horibe, Keizo
Ogawa, Seishi
Hata, Kenichiro
Hayashi, Yasuhide
BLOOD, 2022, 140 : 9134 - 9135
[38] Secondary acute myeloblastic leukaemia (AML) (expressing 11q23 mutation) occurring 11 months after chemotherapy/radiotherapy for paediatric non-Hodgkin lymphoma (NHL)
Taylor, HJH
Gravett, P
Plowman, PN
CLINICAL ONCOLOGY, 2000, 12 (02) : 112 - 114
[39] Chromosome abnormalities in advanced stage T-cell lymphoblastic lymphoma of children and adolescents: a report from Japanese Paediatric Leukaemia/Lymphoma Study Group (JPLSG) and review of the literature
Sekimizu, Masahiro
Sunami, Shosuke
Nakazawa, Atsuko
Hayashi, Yasuhide
Okimoto, Yuri
Saito, Akiko M.
Horibe, Keizo
Tsurusawa, Masahito
Mori, Tetsuya
BRITISH JOURNAL OF HAEMATOLOGY, 2011, 154 (05) : 612 - 617
[40] OUTCOME OF RELAPSED ACUTE LYMPHOBLASTIC LEUKAEMIA: REPORT FROM HONG KONG PAEDIATRIC HAEMATOLOGY AND ONCOLOGY STUDY GROUP (HKPHOSG)
Leung, Wing Kwan
Ha, Shan Yin
Ling, Sin Cheung
Yuen, Hui Leung
Ii, Chak Ho
Li, Chi Kong
PEDIATRIC BLOOD & CANCER, 2010, 55 (05) : 863 - 863

← 1 2 3 4 5 →