Complex and monosomal karyotype are distinct cytogenetic entities with an adverse prognostic impact in paediatric acute myeloid leukaemia. A NOPHO-DBH-AML study

被引：7

作者：

Bager, Ninna ^{[1
]}

Juul-Dam, Kristian L. ^{[1
]}

Sandahl, Julie D. ^{[1
]}

Abrahamsson, Jonas ^{[2
]}

Beverloo, Berna ^{[3
]}

de Bont, Eveline S. J. M. ^{[4
]}

Ha, Shau-Yin ^{[5
]}

Jahnukainen, Kirsi ^{[6
,7
]}

Jonsson, Olafur G. ^{[8
]}

Kaspers, Gertjan L. ^{[9
,10
]}

Kovalova, Zhanna ^{[11
]}

Lausen, Birgitte ^{[12
]}

De Moerloose, Barbara ^{[13
]}

Noren-Nystroem, Ulrika ^{[14
]}

Palle, Josefine ^{[15
]}

Saks, Kadri ^{[16
]}

Zeller, Bernward ^{[17
]}

Kjeldsen, Eigil ^{[18
]}

Hasle, Henrik ^{[1
]}

机构：

[1] Aarhus Univ Hosp, Dept Paediat & Adolescent Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark

[2] Queen Silvia Childrens Hosp, Inst Clin Sci, Dept Paediat, Gothenburg, Sweden

[3] Erasmus MC Sophia Childrens Hosp, Dept Cytogenet, Rotterdam, Netherlands

[4] Univ Med Ctr Groningen, Dept Paediat, Groningen, Netherlands

[5] Queen Mary Hosp, Hong Kong Paediat Haematol & Oncol Study Grp, Dept Paediat, Hong Kong, Hong Kong, Peoples R China

[6] Univ Helsinki, Childrens Hosp, Helsinki, Finland

[7] Helsinki Univ Hosp, Helsinki, Finland

[8] Landspital Inn, Dept Paediat, Reykjavik, Iceland

[9] Vrije Univ Amsterdam Med Ctr, Paediat Oncol Haematol, Amsterdam, Netherlands

[10] Acad Princess Maxima Ctr Paediat Oncol, Utrecht, Netherlands

[11] Childrens Clin Univ Hosp, Dept Paediat, Riga, Latvia

[12] Univ Copenhagen, Rigshosp, Dept Paediat & Adolescent Med, Copenhagen, Denmark

[13] Ghent Univ Hosp, Dept Paediat, Ghent, Belgium

[14] Umea Univ Hosp, Dept Med Biosci, Genet, Umea, Sweden

[15] Uppsala Univ, Dept Womans & Childrens Hlth, Uppsala, Sweden

[16] SA Tallinna Lastehaigla, Dept Paediat, Tallinn, Estonia

[17] Oslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway

[18] Aarhus Univ Hosp, Dept Cytogenet, Aarhus, Denmark

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2018年 / 183卷 / 04期

关键词：

Acute myeloid leukaemia; complex karyotype; monosomal karyotype; refractory disease; paediatrics; CLINICAL CHARACTERISTICS; LEUKEMIA; CHILDREN; THERAPY; ADULT; CHILDHOOD; ABNORMALITIES; RELAPSE; ADOLESCENTS; DIAGNOSIS;

D O I：

10.1111/bjh.15587

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Data on occurrence, genetic characteristics and prognostic impact of complex and monosomal karyotype (CK/MK) in children with acute myeloid leukaemia (AML) are scarce. We studied CK and MK in a large unselected cohort of childhood AML patients diagnosed and treated according to Nordic Society for Paediatric Haematology and Oncology (NOPHO)-AML protocols 1993-2015. In total, 800 patients with de novo AML were included. CK was found in 122 (15%) and MK in 41 (5%) patients. CK and MK patients were young (median age 2.1 and 3.3 years, respectively) and frequently had FAB M7 morphology (24% and 22%, respectively). Refractory disease was more common in MK patients (15% vs. 4%) and stem cell transplantation in first complete remission was more frequent (32% vs. 19%) compared with non-CK/non-MK patients. CK showed no association with refractory disease but was an independent predictor of an inferior event-free survival (EFS; hazard ratio [HR] 1.43, P = 0.03) and overall survival (OS; HR 1.48, P = 0.01). MK was associated with a poor EFS (HR 1.57, P = 0.03) but did not show an inferior OS compared to non-MK patients (HR 1.14, P = 0.62). In a large paediatric cohort, we characterized AML with non-recurrent abnormal karyotype and unravelled the adverse impact of CK and MK on prognosis.

引用

页码：618 / 628

页数：11

共 19 条

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