Predisposition to prolonged neutropenia after chemotherapy for paediatric acute myeloid leukaemia is associated with better prognosis in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study

被引：4

作者：

Aoki, Takahiro ^{[1
]}

Takahashi, Hiroyuki ^{[2
]}

Tanaka, Shiro ^{[3
]}

Shiba, Norio ^{[4
]}

Hasegawa, Daiichiro ^{[5
]}

Iwamoto, Shotaro ^{[6
]}

Terui, Kiminori ^{[7
]}

Moritake, Hiroshi ^{[8
]}

Nakayama, Hideki ^{[9
]}

Shimada, Akira ^{[10
]}

Koh, Katsuyoshi ^{[11
]}

Goto, Hiroaki ^{[12
]}

Kosaka, Yoshiyuki ^{[5
]}

Saito, Akiko M. ^{[13
]}

Horibe, Keizo ^{[13
]}

Kinoshita, Akitoshi ^{[14
]}

Tawa, Akio ^{[15
]}

Taga, Takashi ^{[16
]}

Adachi, Souichi ^{[17
]}

Tomizawa, Daisuke ^{[18
]}

机构：

[1] Chiba Univ, Grad Sch Med, Dept Pediat, Chiba, Japan

[2] Toho Univ, Dept Pediat, Tokyo, Japan

[3] Kyoto Univ, Grad Sch Med, Dept Clin Biostat, Clin Biostat Course, Kyoto, Japan

[4] Yokohama City Univ Med, Grad Sch Med, Dept Pediat, Yokohama, Kanagawa, Japan

[5] Hyogo Prefectural Kobe Childrens Hosp, Dept Hematol Oncol, Kobe, Hyogo, Japan

[6] Mie Univ, Dept Pediat, Tsu, Mie, Japan

[7] Hirosaki Univ, Dept Pediat, Hirosaki, Aomori, Japan

[8] Univ Miyazaki, Fac Med, Div Pediat, Miyazaki, Japan

[9] Natl Hosp Org, Dept Pediat, Kyushu Canc Ctr, Fukuoka, Japan

[10] Okayama Univ Hosp, Dept Pediat Hematol Oncol, Okayama, Japan

[11] Saitama Childrens Med Ctr, Dept Hematol Oncol, Saitama, Japan

[12] Kanagawa Childrens Med Ctr, Div Hematol Oncol, Yokohama, Kanagawa, Japan

[13] Natl Hosp Org, Clin Res Ctr, Nagoya Med Ctr, Nagoya, Aichi, Japan

[14] St Marianna Univ, Sch Med, Dept Pediat, Kawasaki, Kanagawa, Japan

[15] Higashiosaka Aramoto Heiwa Clin, Higashiosaka, Osaka, Japan

[16] Shiga Univ Med Sci, Dept Pediat, Otsu, Shiga, Japan

[17] Kyoto Univ, Dept Human Hlth Sci, Kyoto, Japan

[18] Natl Ctr Child Hlth & Dev, Childrens Canc Ctr, Div Leukemia & Lymphoma, Tokyo, Japan

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2021年 / 193卷 / 01期

关键词：

acute myeloid leukaemia; chemosensitivity; children; myelosuppression; neutropenia; LYMPHOBLASTIC-LEUKEMIA; CHILDREN; RELAPSE; THERAPY;

D O I：

10.1111/bjh.16656

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The variability in myelosuppression after chemotherapy for acute myeloid leukaemia (AML) can affect its prognosis; however, the underlying mechanism remains controversial. In the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study, we showed that prolonged neutropenia was associated with high overall survival (P = 0 center dot 011) and low frequency of relapse (P = 0 center dot 042) in patients without granulocyte-colony stimulating factor (G-CSF) who completed the indicated treatment protocol. Our data indicate that predisposition to prolonged neutropenia after chemotherapy is correlated with a better outcome of AML treatment. Our results promote the usage of individualised drug dosing strategies to improve the therapeutic outcome in AML patients.

引用

页码：176 / 180

页数：5

共 50 条

[41] High-dose methotrexate pharmacokinetics and its impact on prognosis of paediatric acute lymphoblastic leukaemia patients: A population pharmacokinetic study
Chen, Xiaoxiao
Li, Jing
Yu, Liting
Hu, Wenting
Cai, Jiaoyang
Wang, Zhuo
Chen, Changcheng
Zhang, Xin
Xie, Yangyang
Wu, Kefei
Mo, Yixiao
Chen, Jihui
Shen, Shuhong
BRITISH JOURNAL OF HAEMATOLOGY, 2024, 204 (04) : 1354 - 1366
[42] Marked improvements in outcome with chemotherapy alone in paediatric acute myeloid leukaemia: results of the United Kingdom Medical Research Council's 10th AML Trial
Stevens, RF
Hann, IM
Wheatley, K
Gray, RG
BRITISH JOURNAL OF HAEMATOLOGY, 1998, 101 (01) : 130 - 140
[43] Differences in infection prophylaxis measures between paediatric acute myeloid leukaemia study groups within the international Berlin-Frankfurt-Munster (I-BFM) study group
Klein, Kim
Hasle, Henrik
Abrahamsson, Jonas
De Moerloose, Barbara
Kaspers, Gertjan J. L.
BRITISH JOURNAL OF HAEMATOLOGY, 2018, 183 (01) : 87 - 95
[44] Negative CD19 Expression Is Associated with Inferior Relapse-Free Survival in RUNX1-RUNX1T1-Positive Acute Myeloid Leukemia; The Japanese Pediatric Leukemia/Lymphoma Study Group Experience from the AML-05 Study
Imamura, Toshihiko
Sakamoto, Kenichi
Shiba, Norio
Deguchi, Takao
Kiyokawa, Nobutaka
Hashii, Yoshiko
Saito, Akiko
Tomizawa, Daisuke
Taga, Takashi
Adachi, Souichi
BLOOD, 2018, 132
[45] PROLONGED THROMBOCYTOPENIA IN ACUTE MYELOID LEUKAEMIA (AML) PATIENTS TREATED WITH FRACTIONATED DOSES OF GEMTUZUMAB OZOGAMICIN (GO) IN THE ALFA-0701 STUDY DOES NOT CONFER AN ADVERSE PROGNOSIS
Pautas, C.
De Gunzburg, N.
Raffoux, E.
Rigaudeau, S.
Gardin, C.
Berthon, C.
Turlure, P.
Marie, J.
Michallet, M.
Janvier, M.
Caillot, D.
Suarez, F.
Tilly, H.
Reman, O.
Rousselot, P.
Dombret, H.
Chevret, S.
Castaigne, S.
HAEMATOLOGICA, 2012, 97 : 24 - 24
[46] Results of immunosuppressive therapy in children with acquired severe aplastic anaemia (SAA). Report Polish Paediatric Leukaemia and Lymphoma Study Group.
Pawelec, K
Matysiak, M
Niewiadomska, E
Rokicka-Milewska, R
Jackowska, T
Kowalczyk, J
Stefaniak, J
Balwierz, W
Zalecka-Czerpko, E
Chybicka, A
Szmyd, K
Sonta-Jakimczyk, D
Bubala, H
Krauze, A
Wysocki, M
Kurylak, A
Wachowiak, J
Kaczmarek-Karnold, M
Stolarska, M
Karolczyk, I
Krawczuk-Rybak, M
Leszczynska, E
Urasinski, T
Peregud-Pogorzelski, J
Wlazlowski, M
Balcerska, A
BLOOD, 2005, 106 (11) : 16B - 16B
[47] Infectious complications in paediatric acute myeloid leukaemia:: low incidence of bacteraemia due to viridans streptococci in a 10-year retrospective study
Brunet, AS
Ploton
Galambrun, C
Pondarre, C
Pages, MP
Bleyzac, N
Freydière, AM
Barbé, G
Bertrand, Y
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2004, 24 : S102 - S103
[48] Biomarkers to predict infection and infection-related complications during chemotherapy-induced neutropenia in acute myeloid leukaemia: a pilot study
van deGeer, Annemarie
Zandstra, Judith
Tanck, Michael W. T.
Nur, Efran
vanMierlo, Gerard
Jongerius, Ilse
vanBruggen, Robin
Zeerleder, Sacha S.
Kuijpers, Taco W.
BRITISH JOURNAL OF HAEMATOLOGY, 2021, 193 (05) : 1008 - 1012
[49] Clinical and molecular characteristics of paediatric mature B-cell acute lymphocytic leukaemia and non-Hodgkin lymphoma with bone marrow involvement: A joint study between the CCCG leukaemia and lymphoma groups
Zhao, Jie
Liu, Tian-Feng
Wu, Ke-fei
Yang, Liang-Chun
Xu, Xue-Ju
Lu, Jun
Shao, Jing-Bo
Li, Fu
Ma, Fu-Tian
Guo, Xia
Li, Hui
Liu, Ai-Guo
Wang, Ning-Ling
Shen, He-Ping
Li, Yang
Liu, Si-Xi
Liang, Chang-Da
Shen, Shu-Hong
Fang, Yong-Jun
Gao, Yi-Jin
BRITISH JOURNAL OF HAEMATOLOGY, 2025,
[50] Effects of Mylotarg™ (Gemtuzumab ozogomycin, GO) in combination with standard induction chemotherapy in the treatment of acute myeloid leukaemia (AML):: A feasibility study.
Kell, JW
Burnett, AK
Chopra, R
Yin, J
BLOOD, 2001, 98 (11) : 123A - 124A

← 1 2 3 4 5 →