Parallel synthesis of dihydropyrimidinones using Yb(III)-resin and polymer-supported scavengers under solvent-free conditions. A green chemistry approach to the Biginelli reaction

被引：198
|
作者：
Dondoni, A [1 ]
Massi, A [1 ]
机构：
[1] Univ Ferrara, Dipartmento Chim, Chim Organ Lab, I-44100 Ferrara, Italy
来源：
TETRAHEDRON LETTERS | 2001年 / 42卷 / 45期
关键词：
Biginelli reaction; dihydropyrimidinones; polymer-supported reagents; multicomponent reaction;
D O I：
10.1016/S0040-4039(01)01728-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient synthesis of an array of 3,4-dihydropyrimidin-2-(1H)-ones using solid-supported ytterbium(III) reagent from aldehydes, 1,3-dicarbonyl compounds and urea (Biginelli reaction) under solvent-free conditions is described. Purification of each member of the library was carried out using a cocktail of acid and basic polymer-supported scavengers (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：7975 / 7978
页数：4
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